A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy
We retrospectively analyzed therapeutic strategies and risk factors for overall survival (OS) in disease recurrence following curative nephrectomy for localized renal cell carcinoma (loRCC) using the Korean National Cancer Registry Database. We selected 1295 recurrent loRCC patients who underwent ei...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.693831/full |
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| author | Sung Han Kim Min Gee Choi Ji Hye Shin Young-Ae Kim Jinsoo Chung |
| author_facet | Sung Han Kim Min Gee Choi Ji Hye Shin Young-Ae Kim Jinsoo Chung |
| author_sort | Sung Han Kim |
| collection | DOAJ |
| description | We retrospectively analyzed therapeutic strategies and risk factors for overall survival (OS) in disease recurrence following curative nephrectomy for localized renal cell carcinoma (loRCC) using the Korean National Cancer Registry Database. We selected 1295 recurrent loRCC patients who underwent either partial or radical nephrectomy from 2007–2013. Patients were excluded for age <19 years, secondary RCC, multiple primary tumors, other SEER stages except for a localized or regional stage, postoperative recurrence within 3-month, and non-nephrectomized cases. Four therapeutic groups were statistically analyzed for OS and risk factors: surgery (OP, 12.0%), other systemic therapy (OST, 59.5%), radiotherapy (RT, 2.8%), and targeted therapy (TT, 25.8%). The overall mortality rate for recurrent loRCC was 32.5%, including 82.4% for RCC-related deaths. The baseline comparison among groups showed statistical differences for the diagnostic age of cancer and the SEER stage (p<0.05). Multivariate analysis of OS showed significance for the TT (hazard ratio [HR]: 6.27), OST (HR: 7.05), and RT (HR: 7.47) groups compared with the OP group, along with significance for the sex, SEER stage, and the time from nephrectomy to treatment for disease recurrence (p<0.05). The median OS curve showed a significantly better OS in the OP group (54.9 months) compared with the TT, OST, and RT groups (41.7, 42.9, and 38.0 months, respectively; p<0.001). In conclusion, the surgery-treated group had the best OS among the different therapeutic strategies for recurrent loRCC after nephrectomy, and the importance of the time from nephrectomy to secondary treatment was a significant prognostic factor. |
| first_indexed | 2024-12-17T01:14:04Z |
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| id | doaj.art-a318a35f17144673bde9b796b8fabe48 |
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| language | English |
| last_indexed | 2024-12-17T01:14:04Z |
| publishDate | 2021-09-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-a318a35f17144673bde9b796b8fabe482022-12-21T22:09:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.693831693831A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After NephrectomySung Han Kim0Min Gee Choi1Ji Hye Shin2Young-Ae Kim3Jinsoo Chung4Department of Urology, Center for Urologic Cancer, Research Institute and Hospital of National Cancer Center, Goyang, South KoreaNational Cancer Control Institute, National Cancer Center, Goyang, South KoreaNational Cancer Control Institute, National Cancer Center, Goyang, South KoreaNational Cancer Control Institute, National Cancer Center, Goyang, South KoreaDepartment of Urology, Center for Urologic Cancer, Research Institute and Hospital of National Cancer Center, Goyang, South KoreaWe retrospectively analyzed therapeutic strategies and risk factors for overall survival (OS) in disease recurrence following curative nephrectomy for localized renal cell carcinoma (loRCC) using the Korean National Cancer Registry Database. We selected 1295 recurrent loRCC patients who underwent either partial or radical nephrectomy from 2007–2013. Patients were excluded for age <19 years, secondary RCC, multiple primary tumors, other SEER stages except for a localized or regional stage, postoperative recurrence within 3-month, and non-nephrectomized cases. Four therapeutic groups were statistically analyzed for OS and risk factors: surgery (OP, 12.0%), other systemic therapy (OST, 59.5%), radiotherapy (RT, 2.8%), and targeted therapy (TT, 25.8%). The overall mortality rate for recurrent loRCC was 32.5%, including 82.4% for RCC-related deaths. The baseline comparison among groups showed statistical differences for the diagnostic age of cancer and the SEER stage (p<0.05). Multivariate analysis of OS showed significance for the TT (hazard ratio [HR]: 6.27), OST (HR: 7.05), and RT (HR: 7.47) groups compared with the OP group, along with significance for the sex, SEER stage, and the time from nephrectomy to treatment for disease recurrence (p<0.05). The median OS curve showed a significantly better OS in the OP group (54.9 months) compared with the TT, OST, and RT groups (41.7, 42.9, and 38.0 months, respectively; p<0.001). In conclusion, the surgery-treated group had the best OS among the different therapeutic strategies for recurrent loRCC after nephrectomy, and the importance of the time from nephrectomy to secondary treatment was a significant prognostic factor.https://www.frontiersin.org/articles/10.3389/fonc.2021.693831/fullrenal cell carcinomanephrectomytreatmentrecurrenceprognosis |
| spellingShingle | Sung Han Kim Min Gee Choi Ji Hye Shin Young-Ae Kim Jinsoo Chung A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy Frontiers in Oncology renal cell carcinoma nephrectomy treatment recurrence prognosis |
| title | A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy |
| title_full | A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy |
| title_fullStr | A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy |
| title_full_unstemmed | A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy |
| title_short | A Real-World, Population-Based Retrospective Analysis of Therapeutic Survival for Recurrent Localized Renal Cell Carcinoma After Nephrectomy |
| title_sort | real world population based retrospective analysis of therapeutic survival for recurrent localized renal cell carcinoma after nephrectomy |
| topic | renal cell carcinoma nephrectomy treatment recurrence prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.693831/full |
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