<i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina
Background: Coronary artery disease is caused by changes in the coronary arteries due to the atherosclerotic process and thrombotic changes. A very important role in the development of the atherosclerotic process in the coronary vessels is played by the inflammatory process and the immune response....
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MDPI AG
2024-02-01
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| Series: | Journal of Personalized Medicine |
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| author | Damian Malinowski Krzysztof Safranow Andrzej Pawlik |
| author_facet | Damian Malinowski Krzysztof Safranow Andrzej Pawlik |
| author_sort | Damian Malinowski |
| collection | DOAJ |
| description | Background: Coronary artery disease is caused by changes in the coronary arteries due to the atherosclerotic process and thrombotic changes. A very important role in the development of the atherosclerotic process in the coronary vessels is played by the inflammatory process and the immune response. Due to the important role of lipids and the coagulation process in the atherosclerotic process, research has also focused on genes affecting lipid metabolism and the coagulation system. Lipoprotein lipase (LPL) is an enzyme that metabolises lipids, hydrolysing triglycerides to produce free fatty acids and glycerol. Protein C (PC) is an essential component of coagulation and fibrinolysis. It is activated on the endothelial surface by the membrane-bound thrombin-thrombomodulin complex. Platelet-derived growth factor (PDGF) has a number of important functions in processes related to fibroblast and smooth muscle cell function. Due to their influence on lipid metabolism and coagulation processes, LPL, PROCR (endothelial cell protein C receptor) and PDGF may affect the atherosclerotic process and, thus, the risk of coronary heart disease. The aim of the study was to examine the associations between the <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 gene polymorphisms and the risk of unstable angina and selected clinical parameters. Methods: The study included 232 patients with unstable angina and 144 healthy subjects as the control group. Genotyping was performed using real-time PCR. Results: There were no statistically significant differences in the distribution of the polymorphisms tested between the patients with unstable angina and the control subjects. The results showed associations between the <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 polymorphisms and some clinical parameters in patients with unstable angina. In patients with the <i>PDGF</i> rs974819 CC genotype, there were increased values for cholesterol and LDL serum levels in comparison with patients with the <i>PDGF</i> rs974819 CT and TT genotypes. In patients with the <i>PROCR</i> rs867186 AA genotype, HDL serum levels were lower than in patients with the GA genotype. Conclusions: The results of our study did not show that the <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 gene polymorphisms were significant risk factors for unstable angina in our population. The results of the study suggest that <i>PDGF</i> rs974819 and <i>PROCR</i> rs867186 may be associated with some parameters of lipid metabolism. |
| first_indexed | 2024-03-07T22:24:59Z |
| format | Article |
| id | doaj.art-a318f00693f042aa853e58d45a1f26d8 |
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| language | English |
| last_indexed | 2024-03-07T22:24:59Z |
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| spelling | doaj.art-a318f00693f042aa853e58d45a1f26d82024-02-23T15:23:52ZengMDPI AGJournal of Personalized Medicine2075-44262024-02-0114221310.3390/jpm14020213<i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable AnginaDamian Malinowski0Krzysztof Safranow1Andrzej Pawlik2Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandBackground: Coronary artery disease is caused by changes in the coronary arteries due to the atherosclerotic process and thrombotic changes. A very important role in the development of the atherosclerotic process in the coronary vessels is played by the inflammatory process and the immune response. Due to the important role of lipids and the coagulation process in the atherosclerotic process, research has also focused on genes affecting lipid metabolism and the coagulation system. Lipoprotein lipase (LPL) is an enzyme that metabolises lipids, hydrolysing triglycerides to produce free fatty acids and glycerol. Protein C (PC) is an essential component of coagulation and fibrinolysis. It is activated on the endothelial surface by the membrane-bound thrombin-thrombomodulin complex. Platelet-derived growth factor (PDGF) has a number of important functions in processes related to fibroblast and smooth muscle cell function. Due to their influence on lipid metabolism and coagulation processes, LPL, PROCR (endothelial cell protein C receptor) and PDGF may affect the atherosclerotic process and, thus, the risk of coronary heart disease. The aim of the study was to examine the associations between the <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 gene polymorphisms and the risk of unstable angina and selected clinical parameters. Methods: The study included 232 patients with unstable angina and 144 healthy subjects as the control group. Genotyping was performed using real-time PCR. Results: There were no statistically significant differences in the distribution of the polymorphisms tested between the patients with unstable angina and the control subjects. The results showed associations between the <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 polymorphisms and some clinical parameters in patients with unstable angina. In patients with the <i>PDGF</i> rs974819 CC genotype, there were increased values for cholesterol and LDL serum levels in comparison with patients with the <i>PDGF</i> rs974819 CT and TT genotypes. In patients with the <i>PROCR</i> rs867186 AA genotype, HDL serum levels were lower than in patients with the GA genotype. Conclusions: The results of our study did not show that the <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 gene polymorphisms were significant risk factors for unstable angina in our population. The results of the study suggest that <i>PDGF</i> rs974819 and <i>PROCR</i> rs867186 may be associated with some parameters of lipid metabolism.https://www.mdpi.com/2075-4426/14/2/213LPLPROCRPDGFPolymorphismsUnstable Angina |
| spellingShingle | Damian Malinowski Krzysztof Safranow Andrzej Pawlik <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina Journal of Personalized Medicine LPL PROCR PDGF Polymorphisms Unstable Angina |
| title | <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina |
| title_full | <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina |
| title_fullStr | <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina |
| title_full_unstemmed | <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina |
| title_short | <i>LPL</i> rs264, <i>PROCR</i> rs867186 and <i>PDGF</i> rs974819 Gene Polymorphisms in Patients with Unstable Angina |
| title_sort | i lpl i rs264 i procr i rs867186 and i pdgf i rs974819 gene polymorphisms in patients with unstable angina |
| topic | LPL PROCR PDGF Polymorphisms Unstable Angina |
| url | https://www.mdpi.com/2075-4426/14/2/213 |
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