Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5)
Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research too...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506122002367 |
| _version_ | 1811340180077936640 |
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| author | Xing Zhen Woojoo Kang Sang-Je Park Se-Hee Choe Seok-Ho Hong Dong-Seok Lee Jong-Hee Lee |
| author_facet | Xing Zhen Woojoo Kang Sang-Je Park Se-Hee Choe Seok-Ho Hong Dong-Seok Lee Jong-Hee Lee |
| author_sort | Xing Zhen |
| collection | DOAJ |
| description | Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy. |
| first_indexed | 2024-04-13T18:38:08Z |
| format | Article |
| id | doaj.art-a31a22eaade84a509d16c171882434e4 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-13T18:38:08Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-a31a22eaade84a509d16c171882434e42022-12-22T02:34:49ZengElsevierStem Cell Research1873-50612022-10-0164102887Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5)Xing Zhen0Woojoo Kang1Sang-Je Park2Se-Hee Choe3Seok-Ho Hong4Dong-Seok Lee5Jong-Hee Lee6National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Nanoscience and Nanotechnology, Graduate School, Kyungpook National University, Daegu, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of KoreaDepartment of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of KoreaSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea; Corresponding authors at: School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea (D.-S. Lee); National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea (J.-H. Lee).National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea; Corresponding authors at: School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea (D.-S. Lee); National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea (J.-H. Lee).Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (iPSC) derivatives have been used as a research tool to investigate autologous regenerative medicine. Here, we reprogrammed cynomolgus monkey kidney fibroblasts (cmKFs) as a control for animal iPSCs and to study autologous transplant. The resulting cmKF-iPSCs, which displayed canonical characteristics of PSCs, could be used as a unique model for autologous cell-based therapy.http://www.sciencedirect.com/science/article/pii/S1873506122002367 |
| spellingShingle | Xing Zhen Woojoo Kang Sang-Je Park Se-Hee Choe Seok-Ho Hong Dong-Seok Lee Jong-Hee Lee Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) Stem Cell Research |
| title | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) |
| title_full | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) |
| title_fullStr | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) |
| title_full_unstemmed | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) |
| title_short | Generation and characterization of cynomolgus monkey kidney fibroblasts (cmKF)-derived induced pluripotent stem cells (cmKF-iPS-C5) |
| title_sort | generation and characterization of cynomolgus monkey kidney fibroblasts cmkf derived induced pluripotent stem cells cmkf ips c5 |
| url | http://www.sciencedirect.com/science/article/pii/S1873506122002367 |
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