Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis

Loss of the Fbw7 tumor suppressor rewires cholesterol metabolism in cancer cells leading to activation of the PI3K-AKT signalling axis

The sterol regulatory-element binding proteins (SREBPs) are transcription factors controlling cholesterol and fatty acid synthesis and metabolism. There are three SREBP proteins, SREBP1a, SREBP1c and SREBP2, with SREBP1a being the strongest transcription factor. The expression of SREBP1a is restrict...

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Bibliographic Details
Main Authors: Maria T. Bengoechea-Alonso, Arwa Aldaalis, Johan Ericsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
SREBP
Fbw7
PI3K
AKT
cholesterol
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.990672/full

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