HAT1: Landscape of Biological Function and Role in Cancer
Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone prot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/7/1075 |
| _version_ | 1797608201194045440 |
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| author | Vincenza Capone Laura Della Torre Daniela Carannante Mehrad Babaei Lucia Altucci Rosaria Benedetti Vincenzo Carafa |
| author_facet | Vincenza Capone Laura Della Torre Daniela Carannante Mehrad Babaei Lucia Altucci Rosaria Benedetti Vincenzo Carafa |
| author_sort | Vincenza Capone |
| collection | DOAJ |
| description | Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone proteins. This epigenetic modification regulates transcriptional processes and protein activity, stability, and localization. Several studies highlight a specific role for HAT1 in regulating molecular pathways, which are altered in several pathologies, among which is cancer. HAT1 is the first histone acetyltransferase discovered; however, to date, its biological characterization is still unclear. In this review, we summarize and update the current knowledge about the biological function of this acetyltransferase, highlighting recent advances of HAT1 in the pathogenesis of cancer. |
| first_indexed | 2024-03-11T05:41:08Z |
| format | Article |
| id | doaj.art-a31c561b55264dbd822cdac64aa09097 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T05:41:08Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a31c561b55264dbd822cdac64aa090972023-11-17T16:28:56ZengMDPI AGCells2073-44092023-04-01127107510.3390/cells12071075HAT1: Landscape of Biological Function and Role in CancerVincenza Capone0Laura Della Torre1Daniela Carannante2Mehrad Babaei3Lucia Altucci4Rosaria Benedetti5Vincenzo Carafa6Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Vico De Crecchio 7, 80138 Naples, ItalyHistone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone proteins. This epigenetic modification regulates transcriptional processes and protein activity, stability, and localization. Several studies highlight a specific role for HAT1 in regulating molecular pathways, which are altered in several pathologies, among which is cancer. HAT1 is the first histone acetyltransferase discovered; however, to date, its biological characterization is still unclear. In this review, we summarize and update the current knowledge about the biological function of this acetyltransferase, highlighting recent advances of HAT1 in the pathogenesis of cancer.https://www.mdpi.com/2073-4409/12/7/1075epigeneticsacetylationHAT1cancerinflammation |
| spellingShingle | Vincenza Capone Laura Della Torre Daniela Carannante Mehrad Babaei Lucia Altucci Rosaria Benedetti Vincenzo Carafa HAT1: Landscape of Biological Function and Role in Cancer Cells epigenetics acetylation HAT1 cancer inflammation |
| title | HAT1: Landscape of Biological Function and Role in Cancer |
| title_full | HAT1: Landscape of Biological Function and Role in Cancer |
| title_fullStr | HAT1: Landscape of Biological Function and Role in Cancer |
| title_full_unstemmed | HAT1: Landscape of Biological Function and Role in Cancer |
| title_short | HAT1: Landscape of Biological Function and Role in Cancer |
| title_sort | hat1 landscape of biological function and role in cancer |
| topic | epigenetics acetylation HAT1 cancer inflammation |
| url | https://www.mdpi.com/2073-4409/12/7/1075 |
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