Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species
<i>Yersinia pseudotuberculosis</i>, <i>Y. enterocolitica</i> and <i>Y. pestis</i> are pathogenic bacteria capable of causing disease in humans by growing extracellularly in lymph nodes and during systemic infections. While the capacity of these bacteria to invade,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/12/1637 |
| _version_ | 1797545680995090432 |
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| author | Marion Lemarignier Javier Pizarro-Cerdá |
| author_facet | Marion Lemarignier Javier Pizarro-Cerdá |
| author_sort | Marion Lemarignier |
| collection | DOAJ |
| description | <i>Yersinia pseudotuberculosis</i>, <i>Y. enterocolitica</i> and <i>Y. pestis</i> are pathogenic bacteria capable of causing disease in humans by growing extracellularly in lymph nodes and during systemic infections. While the capacity of these bacteria to invade, replicate, and survive within host cells has been known for long, it is only in recent years that their intracellular stages have been explored in more detail. Current evidence suggests that pathogenic <i>Yersinia</i> are capable of activating autophagy in both phagocytic and epithelial cells, subverting autophagosome formation to create a niche supporting bacterial intracellular replication. In this review, we discuss recent results opening novel perspectives to the understanding of intimate host-pathogens interactions taking place during enteric yersiniosis and plague. |
| first_indexed | 2024-03-10T14:18:40Z |
| format | Article |
| id | doaj.art-a31cf6debe0d4b08b8fee259e4316500 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T14:18:40Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a31cf6debe0d4b08b8fee259e43165002023-11-20T23:34:25ZengMDPI AGBiomolecules2218-273X2020-12-011012163710.3390/biom10121637Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> SpeciesMarion Lemarignier0Javier Pizarro-Cerdá1Yersinia Research Unit, Institut Pasteur, F-75015 Paris, FranceYersinia Research Unit, Institut Pasteur, F-75015 Paris, France<i>Yersinia pseudotuberculosis</i>, <i>Y. enterocolitica</i> and <i>Y. pestis</i> are pathogenic bacteria capable of causing disease in humans by growing extracellularly in lymph nodes and during systemic infections. While the capacity of these bacteria to invade, replicate, and survive within host cells has been known for long, it is only in recent years that their intracellular stages have been explored in more detail. Current evidence suggests that pathogenic <i>Yersinia</i> are capable of activating autophagy in both phagocytic and epithelial cells, subverting autophagosome formation to create a niche supporting bacterial intracellular replication. In this review, we discuss recent results opening novel perspectives to the understanding of intimate host-pathogens interactions taking place during enteric yersiniosis and plague.https://www.mdpi.com/2218-273X/10/12/1637<i>Yersinia enterocolitica</i><i>Y. pseudotuberculosis</i><i>Y. pestis</i><i>Y. ruckeri</i>autophagyenteric yersiniosis |
| spellingShingle | Marion Lemarignier Javier Pizarro-Cerdá Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species Biomolecules <i>Yersinia enterocolitica</i> <i>Y. pseudotuberculosis</i> <i>Y. pestis</i> <i>Y. ruckeri</i> autophagy enteric yersiniosis |
| title | Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species |
| title_full | Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species |
| title_fullStr | Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species |
| title_full_unstemmed | Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species |
| title_short | Autophagy and Intracellular Membrane Trafficking Subversion by Pathogenic <i>Yersinia</i> Species |
| title_sort | autophagy and intracellular membrane trafficking subversion by pathogenic i yersinia i species |
| topic | <i>Yersinia enterocolitica</i> <i>Y. pseudotuberculosis</i> <i>Y. pestis</i> <i>Y. ruckeri</i> autophagy enteric yersiniosis |
| url | https://www.mdpi.com/2218-273X/10/12/1637 |
| work_keys_str_mv | AT marionlemarignier autophagyandintracellularmembranetraffickingsubversionbypathogeniciyersiniaispecies AT javierpizarrocerda autophagyandintracellularmembranetraffickingsubversionbypathogeniciyersiniaispecies |