Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population
Abstract Background Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-glutamyl transpeptidase to lymphocyte ratio (GLR) are assumed to be prognostic factors in liver fibrosis, cirrhosis and hepatocellular carcinoma. However, the reference values of GPR and GLR were not known. Objective...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-022-02509-1 |
| _version_ | 1811328543092637696 |
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| author | Weijie Chen Danmian Hong Zeliang Chen Xiaoqing Dai Jing Cao Min Yu Liping Li |
| author_facet | Weijie Chen Danmian Hong Zeliang Chen Xiaoqing Dai Jing Cao Min Yu Liping Li |
| author_sort | Weijie Chen |
| collection | DOAJ |
| description | Abstract Background Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-glutamyl transpeptidase to lymphocyte ratio (GLR) are assumed to be prognostic factors in liver fibrosis, cirrhosis and hepatocellular carcinoma. However, the reference values of GPR and GLR were not known. Objectives The study aimed to investigate the reference ranges of GPR and GLR in Chinese Han population in Chaoshan region in South China. Methods A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. 2400 healthy adults aged 20~79 years were included. GPR and GLR were determined. Results Of 2400 healthy adults, 1200 men and 1200 women were included. The median GPR and GLR for men were 0.22 and 11.28, for women were 0.18 and 7.86, respectively. The 95% reference range of GPR in normal male and female are 0.09~0.54 and 0.08~0.55, GLR are 4.55~29.64 and 3.52~23.08, respectively. The male had a higher GPR at age 20~49 than the female while the GPR at age 60~79 was higher in the female than in the male. The GPR was affected by age, decreased with aging in male and increased in female. The GLR was higher in the male than in the female and varied with aging in the female but not in the male. Conclusion The study provides reference data on GPR and GLR from different age and sex groups in South China. GPR and GLR varied with age and sex. |
| first_indexed | 2024-04-13T15:27:02Z |
| format | Article |
| id | doaj.art-a31e29f00de44ef0b7accae460e84690 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-13T15:27:02Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-a31e29f00de44ef0b7accae460e846902022-12-22T02:41:29ZengBMCBMC Gastroenterology1471-230X2022-10-012211510.1186/s12876-022-02509-1Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han populationWeijie Chen0Danmian Hong1Zeliang Chen2Xiaoqing Dai3Jing Cao4Min Yu5Liping Li6The First Affiliated Hospital, Shantou University Medical CollegeThe First Affiliated Hospital, Shantou University Medical CollegeThe First Affiliated Hospital, Shantou University Medical CollegeThe First Affiliated Hospital, Shantou University Medical CollegeThe First Affiliated Hospital, Shantou University Medical CollegeThe First Affiliated Hospital, Shantou University Medical CollegeSchool of Public Health, Shantou UniversityAbstract Background Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-glutamyl transpeptidase to lymphocyte ratio (GLR) are assumed to be prognostic factors in liver fibrosis, cirrhosis and hepatocellular carcinoma. However, the reference values of GPR and GLR were not known. Objectives The study aimed to investigate the reference ranges of GPR and GLR in Chinese Han population in Chaoshan region in South China. Methods A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. 2400 healthy adults aged 20~79 years were included. GPR and GLR were determined. Results Of 2400 healthy adults, 1200 men and 1200 women were included. The median GPR and GLR for men were 0.22 and 11.28, for women were 0.18 and 7.86, respectively. The 95% reference range of GPR in normal male and female are 0.09~0.54 and 0.08~0.55, GLR are 4.55~29.64 and 3.52~23.08, respectively. The male had a higher GPR at age 20~49 than the female while the GPR at age 60~79 was higher in the female than in the male. The GPR was affected by age, decreased with aging in male and increased in female. The GLR was higher in the male than in the female and varied with aging in the female but not in the male. Conclusion The study provides reference data on GPR and GLR from different age and sex groups in South China. GPR and GLR varied with age and sex.https://doi.org/10.1186/s12876-022-02509-1Gamma-glutamyl transpeptidase to platelet ratioGamma-glutamyl transpeptidase to lymphocyte ratioReference range |
| spellingShingle | Weijie Chen Danmian Hong Zeliang Chen Xiaoqing Dai Jing Cao Min Yu Liping Li Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population BMC Gastroenterology Gamma-glutamyl transpeptidase to platelet ratio Gamma-glutamyl transpeptidase to lymphocyte ratio Reference range |
| title | Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population |
| title_full | Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population |
| title_fullStr | Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population |
| title_full_unstemmed | Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population |
| title_short | Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population |
| title_sort | gamma glutamyl transpeptidase to platelet and gamma glutamyl transpeptidase to lymphocyte ratio in a sample of chinese han population |
| topic | Gamma-glutamyl transpeptidase to platelet ratio Gamma-glutamyl transpeptidase to lymphocyte ratio Reference range |
| url | https://doi.org/10.1186/s12876-022-02509-1 |
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