Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy
The protein kinase D (PKD) family is a family of serine-threonine kinases that are members of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been increasingly implicated in multiple pivotal cellular processes and pathological conditions. PKD dysregulation is associated with se...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.680221/full |
| _version_ | 1818863222683336704 |
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| author | Die Lv Hongli Chen Yun Feng Bomiao Cui Yingzhu Kang Ping Zhang Min Luo Jiao Chen |
| author_facet | Die Lv Hongli Chen Yun Feng Bomiao Cui Yingzhu Kang Ping Zhang Min Luo Jiao Chen |
| author_sort | Die Lv |
| collection | DOAJ |
| description | The protein kinase D (PKD) family is a family of serine-threonine kinases that are members of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been increasingly implicated in multiple pivotal cellular processes and pathological conditions. PKD dysregulation is associated with several diseases, including cancer, inflammation, and obesity. Over the past few years, small-molecule inhibitors have emerged as alternative targeted therapy with fewer adverse side effects than currently available chemotherapy, and these specifically targeted inhibitors limit non-specific toxicities. The successful development of PKD inhibitors would significantly suppress the growth and proliferation of various cancers and inhibit the progression of other diseases. Various PKD inhibitors have been studied in the preclinical setting. In this context, we summarize the PKD inhibitors under investigation and their application for different kinds of diseases. |
| first_indexed | 2024-12-19T10:12:20Z |
| format | Article |
| id | doaj.art-a31ee257cdc3404ab4012218568e35c6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T10:12:20Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a31ee257cdc3404ab4012218568e35c62022-12-21T20:26:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.680221680221Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic StrategyDie LvHongli ChenYun FengBomiao CuiYingzhu KangPing ZhangMin LuoJiao ChenThe protein kinase D (PKD) family is a family of serine-threonine kinases that are members of the calcium/calmodulin-dependent kinase (CaMK) superfamily. PKDs have been increasingly implicated in multiple pivotal cellular processes and pathological conditions. PKD dysregulation is associated with several diseases, including cancer, inflammation, and obesity. Over the past few years, small-molecule inhibitors have emerged as alternative targeted therapy with fewer adverse side effects than currently available chemotherapy, and these specifically targeted inhibitors limit non-specific toxicities. The successful development of PKD inhibitors would significantly suppress the growth and proliferation of various cancers and inhibit the progression of other diseases. Various PKD inhibitors have been studied in the preclinical setting. In this context, we summarize the PKD inhibitors under investigation and their application for different kinds of diseases.https://www.frontiersin.org/articles/10.3389/fonc.2021.680221/fullprotein kinase Dsmall-molecule inhibitorfunctiontherapeuticsdiseases |
| spellingShingle | Die Lv Hongli Chen Yun Feng Bomiao Cui Yingzhu Kang Ping Zhang Min Luo Jiao Chen Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy Frontiers in Oncology protein kinase D small-molecule inhibitor function therapeutics diseases |
| title | Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy |
| title_full | Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy |
| title_fullStr | Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy |
| title_full_unstemmed | Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy |
| title_short | Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy |
| title_sort | small molecule inhibitor targeting protein kinase d a potential therapeutic strategy |
| topic | protein kinase D small-molecule inhibitor function therapeutics diseases |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.680221/full |
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