Mature rat hepatocyte dedifferentiation into long lived proliferating hepatic progenitor cells

Mature rat hepatocyte dedifferentiation into long lived proliferating hepatic progenitor cells

Objective: to obtain long-lived proliferating cells with progenitor features by dedifferentiation of mature rat hepatocytes using combinations of small molecules.Materials and Methods. Hepatocytes isolated from rat liver by perfusion were cultured in the presence of a cocktail of three small molecul...

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Bibliographic Details
Main Authors: A. M. Grigoriev, I. V. Kholodenko, A. Y. Lupatov, R. V. Kholodenko, L. A. Kirsanova, Y. B. Basok, K. N. Yarygin, V. I. Sevastianov
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2021-09-01
Series:Vestnik Transplantologii i Iskusstvennyh Organov
Subjects:
hepatocytes
dedifferentiation
hepatic progenitor cells
small molecules
signaling pathways
y-27632
a-83-01
chir99021
Online Access:https://journal.transpl.ru/vtio/article/view/1383

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