Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma
Differentiation between adult T-cell leukemia/lymphoma (ATLL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is often challenging based on pathological findings alone. Although serum anti-HTLV-1 antibody positivity is required for ATLL diagnosis, this information is often not av...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/5/766 |
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| author | Atsuko Nasu Yuka Gion Yoshito Nishimura Asami Nishikori Misa Sakamoto Yuria Egusa Azusa Fujita Tadashi Yoshino Yasuharu Sato |
| author_facet | Atsuko Nasu Yuka Gion Yoshito Nishimura Asami Nishikori Misa Sakamoto Yuria Egusa Azusa Fujita Tadashi Yoshino Yasuharu Sato |
| author_sort | Atsuko Nasu |
| collection | DOAJ |
| description | Differentiation between adult T-cell leukemia/lymphoma (ATLL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is often challenging based on pathological findings alone. Although serum anti-HTLV-1 antibody positivity is required for ATLL diagnosis, this information is often not available at the time of pathological diagnosis. Therefore, we examined whether the expression of SOX4 and p16 would be helpful for differentiating the two disease entities. We immunohistochemically examined SOX4 and p16 expression (which have been implicated in ATLL carcinogenesis) in 11 ATLL patients and 20 PTCL-NOS patients and classified them into four stages according to the percentage of positive cells. Among the ATLL cases, 8/11 (73%) were SOX4-positive, while only 2/20 (10%) PTCL-NOS cases expressed SOX4. The mean total score was 4.2 (standard deviation (SD): 0.61) in the ATLL group and 0.50 (SD: 0.46) in the PTCL-NOS group (<i>p</i> < 0.001). Positive expression of p16 was noted in 4/11 (36%) patients with ATLL and 3/20 (15%) patients with PTCL-NOS, with mean total scores of 1.9 (SD: 0.64) and 0.70 (SD: 0.48) in the ATLL and PTCL-NOS groups, respectively (<i>p</i> = 0.141). These results suggest that SOX4 may be strongly expressed in ATLL compared to PTCL-NOS cases. Therefore, it may be helpful to perform immunohistochemical staining of SOX4 when pathologists face challenges discriminating between ATLL and PTCL-NOS. |
| first_indexed | 2024-03-10T12:01:07Z |
| format | Article |
| id | doaj.art-a31f219985144decb65c54912a288e77 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T12:01:07Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-a31f219985144decb65c54912a288e772023-11-21T16:59:07ZengMDPI AGDiagnostics2075-44182021-04-0111576610.3390/diagnostics11050766Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/LymphomaAtsuko Nasu0Yuka Gion1Yoshito Nishimura2Asami Nishikori3Misa Sakamoto4Yuria Egusa5Azusa Fujita6Tadashi Yoshino7Yasuharu Sato8Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDepartment of General Medicine, Okayama University Hospital, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDepartment of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDifferentiation between adult T-cell leukemia/lymphoma (ATLL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is often challenging based on pathological findings alone. Although serum anti-HTLV-1 antibody positivity is required for ATLL diagnosis, this information is often not available at the time of pathological diagnosis. Therefore, we examined whether the expression of SOX4 and p16 would be helpful for differentiating the two disease entities. We immunohistochemically examined SOX4 and p16 expression (which have been implicated in ATLL carcinogenesis) in 11 ATLL patients and 20 PTCL-NOS patients and classified them into four stages according to the percentage of positive cells. Among the ATLL cases, 8/11 (73%) were SOX4-positive, while only 2/20 (10%) PTCL-NOS cases expressed SOX4. The mean total score was 4.2 (standard deviation (SD): 0.61) in the ATLL group and 0.50 (SD: 0.46) in the PTCL-NOS group (<i>p</i> < 0.001). Positive expression of p16 was noted in 4/11 (36%) patients with ATLL and 3/20 (15%) patients with PTCL-NOS, with mean total scores of 1.9 (SD: 0.64) and 0.70 (SD: 0.48) in the ATLL and PTCL-NOS groups, respectively (<i>p</i> = 0.141). These results suggest that SOX4 may be strongly expressed in ATLL compared to PTCL-NOS cases. Therefore, it may be helpful to perform immunohistochemical staining of SOX4 when pathologists face challenges discriminating between ATLL and PTCL-NOS.https://www.mdpi.com/2075-4418/11/5/766SOX4p16adult T-cell leukemia/lymphomaperipheral T-cell lymphoma, not otherwise specified |
| spellingShingle | Atsuko Nasu Yuka Gion Yoshito Nishimura Asami Nishikori Misa Sakamoto Yuria Egusa Azusa Fujita Tadashi Yoshino Yasuharu Sato Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma Diagnostics SOX4 p16 adult T-cell leukemia/lymphoma peripheral T-cell lymphoma, not otherwise specified |
| title | Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma |
| title_full | Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma |
| title_fullStr | Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma |
| title_full_unstemmed | Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma |
| title_short | Diagnostic Utility of SOX4 Expression in Adult T-Cell Leukemia/Lymphoma |
| title_sort | diagnostic utility of sox4 expression in adult t cell leukemia lymphoma |
| topic | SOX4 p16 adult T-cell leukemia/lymphoma peripheral T-cell lymphoma, not otherwise specified |
| url | https://www.mdpi.com/2075-4418/11/5/766 |
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