Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver
Background: Optimal duration for medical therapy of liver hydatid cysts before surgery in not certainly defined yet. In this study, we aimed to evaluate the effectiveness of 2 weeks preoperative albendazole in decreasing viable cysts. Methods: Patients referring to Imam Reza Hospital, Mashhad, I...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-12-01
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| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3533 |
| _version_ | 1828113833744400384 |
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| author | Ali Vahidirad Mostafa Mansouri Ali Shamshirian Fariba Berenji Mohammad Reza Motie |
| author_facet | Ali Vahidirad Mostafa Mansouri Ali Shamshirian Fariba Berenji Mohammad Reza Motie |
| author_sort | Ali Vahidirad |
| collection | DOAJ |
| description |
Background: Optimal duration for medical therapy of liver hydatid cysts before surgery in not certainly defined yet. In this study, we aimed to evaluate the effectiveness of 2 weeks preoperative albendazole in decreasing viable cysts.
Methods: Patients referring to Imam Reza Hospital, Mashhad, Iran with a diagnosis of hepatic hydatid cyst were randomly divided into intervention (44 patients) and control (46 patients) groups. The case group were treated with oral albendazole before surgery and the control group underwent surgery without albendazole therapy. Efficacy of albendazole on the reduction of prevalence and viability of the protoscoleces was finally evaluated.
Results: A number of 90 patients were included in the final analysis. Protoscoleces were reported alive in 10 (22.7%) and 17 (36.9%) of patients in the case and control group, respectively. The decrease of live protoscoleces in case group was not statistically significant (P=0.14).
Conclusion: Decrease in the viability of protoscoleces in hepatic hydatid cysts after 2 weeks administration of oral albendazole at a dose of 10 mg/kg/day preoperatively, is not significant. Optimal duration of medical treatment before surgery seems to be 4 weeks or more.
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| first_indexed | 2024-04-11T12:16:26Z |
| format | Article |
| id | doaj.art-a31f68a52d9e44d388886acb3d9a6787 |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-04-11T12:16:26Z |
| publishDate | 2022-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-a31f68a52d9e44d388886acb3d9a67872022-12-22T04:24:19ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2022-12-0117410.18502/ijpa.v17i4.11274Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the LiverAli Vahidirad0Mostafa Mansouri1Ali Shamshirian2Fariba Berenji3Mohammad Reza Motie4Department of Surgery, Golestan University of Medical Sciences, Gorgan, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Background: Optimal duration for medical therapy of liver hydatid cysts before surgery in not certainly defined yet. In this study, we aimed to evaluate the effectiveness of 2 weeks preoperative albendazole in decreasing viable cysts. Methods: Patients referring to Imam Reza Hospital, Mashhad, Iran with a diagnosis of hepatic hydatid cyst were randomly divided into intervention (44 patients) and control (46 patients) groups. The case group were treated with oral albendazole before surgery and the control group underwent surgery without albendazole therapy. Efficacy of albendazole on the reduction of prevalence and viability of the protoscoleces was finally evaluated. Results: A number of 90 patients were included in the final analysis. Protoscoleces were reported alive in 10 (22.7%) and 17 (36.9%) of patients in the case and control group, respectively. The decrease of live protoscoleces in case group was not statistically significant (P=0.14). Conclusion: Decrease in the viability of protoscoleces in hepatic hydatid cysts after 2 weeks administration of oral albendazole at a dose of 10 mg/kg/day preoperatively, is not significant. Optimal duration of medical treatment before surgery seems to be 4 weeks or more. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3533AlbendazoleHydatid cystEchinococcus granulosus |
| spellingShingle | Ali Vahidirad Mostafa Mansouri Ali Shamshirian Fariba Berenji Mohammad Reza Motie Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver Iranian Journal of Parasitology Albendazole Hydatid cyst Echinococcus granulosus |
| title | Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver |
| title_full | Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver |
| title_fullStr | Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver |
| title_full_unstemmed | Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver |
| title_short | Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver |
| title_sort | efficacy of preoperative albendazole on protoscoleces viability in hydatid cyst of the liver |
| topic | Albendazole Hydatid cyst Echinococcus granulosus |
| url | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3533 |
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