Warfarin Resisance and Recurrent Thrombosis in an Iranian Patient
Warfarin resisance was known as subtherapeutic INR (International Normalized Ratio) in spite of normally prescribed doses of warfarin. There are few reports of warfarin resisance from Iran. In this article, we report a 43-year-old man with a hisory of deep vein thrombosis who took 10 mg of warfarin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2019-01-01
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| Series: | Case Reports in Clinical Practice |
| Subjects: | |
| Online Access: | https://crcp.tums.ac.ir/index.php/crcp/article/view/214 |
| Summary: | Warfarin resisance was known as subtherapeutic INR (International Normalized Ratio) in spite of normally prescribed doses of warfarin. There are few reports of warfarin resisance from Iran. In this article, we report a 43-year-old man with a hisory of deep vein thrombosis who took 10 mg of warfarin and 120 mg of enoxaparin daily. He was presented with new acute deep vein thrombosis while taking anticoagulants. Despite warfarin dose increase to 50 mg, the INR did not achieve the therapeutic level. His genetic tesing was negative for VKORC1 mutation but positive for CYP2C9*3, which proposed other underlying mechanisms for his warfarin resisance. This report added to the cases of warfarin resisance in Iran and herald more attention to warfarin metabolism and its interaction. Also it calls for checking serum warfarin level and Factor II and Factor X level for better evaluating compliance in patients presented with warfarin resistance. |
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| ISSN: | 2538-2683 2538-2691 |