Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Abstract Postoperative adjuvant chemotherapy (AC) for poor responders to neoadjuvant chemoradiotherapy (nCRT) remains debatable among patients with locally advanced rectal cancer (LARC), necessitating biomarkers to accurately predict the benefits of AC. This study aimed to develop a patient‐derived...

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Bibliographic Details
Main Authors: Weisong Xue, Ting Wang, Jiaxin Yao, Wei Wu, Dexin Chen, Botao Yan, Xiaoyu Dong, Yuting Tang, Yunli Zeng, Yueyu He, Peihua Cao, Fangyuan Shao, Wenhua Huang, Chuxia Deng, Jun Yan
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Bioengineering & Translational Medicine
Subjects:
adjuvant chemotherapy
neoadjuvant chemoradiotherapy
nomogram
organoid
rectal cancer
Online Access:https://doi.org/10.1002/btm2.10586

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