Programmed Cell Death in Liver Fibrosis
Ruoyu Gao,1 Haiying Tang,2 Jingwei Mao1 1Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, 116011,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-09-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/programmed-cell-death-in-liver-fibrosis-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797694053990531072 |
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| author | Gao R Tang H Mao J |
| author_facet | Gao R Tang H Mao J |
| author_sort | Gao R |
| collection | DOAJ |
| description | Ruoyu Gao,1 Haiying Tang,2 Jingwei Mao1 1Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of ChinaCorrespondence: Jingwei Mao, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, Liaoning Province, People’s Republic of China, Email maojingwei@dmu.edu.cnAbstract: Programmed cell death (PCD) is a comprehensive term that encompasses various forms of cell death, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, which play a crucial role in the pathogenesis of liver fibrosis. PCD facilitates the elimination of aberrant cells, particularly activated hepatic stellate cells (HSCs), which are the primary producers of extracellular matrix (ECM). The removal of HSCs may impede ECM synthesis, thereby mitigating liver fibrosis. As such, PCD has emerged as a promising therapeutic target for the development of novel drugs to treat liver fibrosis. Numerous studies have been conducted to investigate the underlying mechanisms of PCD in the elimination of activated HSCs and other aberrant liver cells in fibrotic liver tissue, including hepatocytes, hepatic sinusoid endothelial cells (LSECs), and Kupffer cells (KCs). The induction of PCD, the interplay between different forms of PCD, and the potential harm or benefit of PCD in liver fibrosis are topics of ongoing research. Evidences suggest that PCD is a complex process with dual effects on liver fibrosis. The purpose of this review is to summarize the most recent advances in PCD and liver fibrosis research.Keywords: liver fibrosis, necroptosis, pyroptosis, ferroptosis, autophagy, apoptosis |
| first_indexed | 2024-03-12T02:52:25Z |
| format | Article |
| id | doaj.art-a321055491c54ad28d8353b9ab9ac7a4 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-12T02:52:25Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-a321055491c54ad28d8353b9ab9ac7a42023-09-03T19:02:41ZengDove Medical PressJournal of Inflammation Research1178-70312023-09-01Volume 163897391086348Programmed Cell Death in Liver FibrosisGao RTang HMao JRuoyu Gao,1 Haiying Tang,2 Jingwei Mao1 1Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, People’s Republic of ChinaCorrespondence: Jingwei Mao, Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, Liaoning Province, People’s Republic of China, Email maojingwei@dmu.edu.cnAbstract: Programmed cell death (PCD) is a comprehensive term that encompasses various forms of cell death, such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, which play a crucial role in the pathogenesis of liver fibrosis. PCD facilitates the elimination of aberrant cells, particularly activated hepatic stellate cells (HSCs), which are the primary producers of extracellular matrix (ECM). The removal of HSCs may impede ECM synthesis, thereby mitigating liver fibrosis. As such, PCD has emerged as a promising therapeutic target for the development of novel drugs to treat liver fibrosis. Numerous studies have been conducted to investigate the underlying mechanisms of PCD in the elimination of activated HSCs and other aberrant liver cells in fibrotic liver tissue, including hepatocytes, hepatic sinusoid endothelial cells (LSECs), and Kupffer cells (KCs). The induction of PCD, the interplay between different forms of PCD, and the potential harm or benefit of PCD in liver fibrosis are topics of ongoing research. Evidences suggest that PCD is a complex process with dual effects on liver fibrosis. The purpose of this review is to summarize the most recent advances in PCD and liver fibrosis research.Keywords: liver fibrosis, necroptosis, pyroptosis, ferroptosis, autophagy, apoptosishttps://www.dovepress.com/programmed-cell-death-in-liver-fibrosis-peer-reviewed-fulltext-article-JIRliver fibrosisnecroptosispyroptosisferroptosisautophagyapoptosis |
| spellingShingle | Gao R Tang H Mao J Programmed Cell Death in Liver Fibrosis Journal of Inflammation Research liver fibrosis necroptosis pyroptosis ferroptosis autophagy apoptosis |
| title | Programmed Cell Death in Liver Fibrosis |
| title_full | Programmed Cell Death in Liver Fibrosis |
| title_fullStr | Programmed Cell Death in Liver Fibrosis |
| title_full_unstemmed | Programmed Cell Death in Liver Fibrosis |
| title_short | Programmed Cell Death in Liver Fibrosis |
| title_sort | programmed cell death in liver fibrosis |
| topic | liver fibrosis necroptosis pyroptosis ferroptosis autophagy apoptosis |
| url | https://www.dovepress.com/programmed-cell-death-in-liver-fibrosis-peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT gaor programmedcelldeathinliverfibrosis AT tangh programmedcelldeathinliverfibrosis AT maoj programmedcelldeathinliverfibrosis |