Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players
According to the literature, the genetic makeup of athletes contributes to their athletic performance. Athletic performance depends on genetic and environmental factors relating to the athlete. The study of sports genetics includes extensive research into identifying genes that affect athletic perfo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Selcuk University
2021-08-01
|
| Series: | Türk Spor ve Egzersiz Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1669860 |
| _version_ | 1797500723322159104 |
|---|---|
| author | Beste Tacal Aslan Özlem Özge Yılmaz Tolga Polat Çisem Şılar Başak Funda Eken Canan Sercan Doğan Korkut Ulucan |
| author_facet | Beste Tacal Aslan Özlem Özge Yılmaz Tolga Polat Çisem Şılar Başak Funda Eken Canan Sercan Doğan Korkut Ulucan |
| author_sort | Beste Tacal Aslan |
| collection | DOAJ |
| description | According to the literature, the genetic makeup of athletes contributes to their athletic performance. Athletic performance depends on genetic and environmental factors relating to the athlete. The study of sports genetics includes extensive research into identifying genes that affect athletic performance. Psychological factors affect athletic performance and so dopamine contributes to the determination of that performance. One of the neurotransmitters of the dopaminergic system is dopamine, which affects the athlete mentally and psychologically. The dopamine receptor D2 (DRD2) rs1800497 polymorphism affects the brain’s dopaminergic system and athletic performance. This study aimed to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in football players and compare them with the control group. For this purpose, 21 football players were enrolled in our study. Genotyping was performed by PCR after DNAs were isolated from buccal epithelial cells. When we examined the genotype distributions, the AG and GG were found as 5 (24%) and 16 (76%), respectively. No AA genotype was found for DRD2. When allelic distributions were examined in the athlete group, the A allele was counted as 5 (12%) and the G allele as 37 (88%). In our study cohort, the DRD2 rs1800497 polymorphism was found to be dominated by the GG genotype and the G allele. We believe that the DRD2 A allele is associated with addiction and thus with athletic performance. However, more studies with athletes from different branches are needed to reveal the effect of DRD2 rs1800497 polymorphism on athletic performance. |
| first_indexed | 2024-03-10T03:07:56Z |
| format | Article |
| id | doaj.art-a321b27fcc0c42f7b6aa633514bdc869 |
| institution | Directory Open Access Journal |
| issn | 2147-5652 |
| language | English |
| last_indexed | 2024-03-10T03:07:56Z |
| publishDate | 2021-08-01 |
| publisher | Selcuk University |
| record_format | Article |
| series | Türk Spor ve Egzersiz Dergisi |
| spelling | doaj.art-a321b27fcc0c42f7b6aa633514bdc8692023-11-23T10:32:09ZengSelcuk UniversityTürk Spor ve Egzersiz Dergisi2147-56522021-08-01232185189154Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football PlayersBeste Tacal Aslan0Özlem Özge Yılmaz1Tolga Polat2Çisem Şılar3Başak Funda Eken4Canan Sercan Doğan5Korkut Ulucan6Marmara University Faculty of Dentistry Department of Basic Medical Sciences/ Medical Biology and GeneticsMARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİmarmara universityMARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİMARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİÜSKÜDAR ÜNİVERSİTESİMARMARA ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİAccording to the literature, the genetic makeup of athletes contributes to their athletic performance. Athletic performance depends on genetic and environmental factors relating to the athlete. The study of sports genetics includes extensive research into identifying genes that affect athletic performance. Psychological factors affect athletic performance and so dopamine contributes to the determination of that performance. One of the neurotransmitters of the dopaminergic system is dopamine, which affects the athlete mentally and psychologically. The dopamine receptor D2 (DRD2) rs1800497 polymorphism affects the brain’s dopaminergic system and athletic performance. This study aimed to determine the genotype and allele distributions of the DRD2 rs180047 polymorphism in football players and compare them with the control group. For this purpose, 21 football players were enrolled in our study. Genotyping was performed by PCR after DNAs were isolated from buccal epithelial cells. When we examined the genotype distributions, the AG and GG were found as 5 (24%) and 16 (76%), respectively. No AA genotype was found for DRD2. When allelic distributions were examined in the athlete group, the A allele was counted as 5 (12%) and the G allele as 37 (88%). In our study cohort, the DRD2 rs1800497 polymorphism was found to be dominated by the GG genotype and the G allele. We believe that the DRD2 A allele is associated with addiction and thus with athletic performance. However, more studies with athletes from different branches are needed to reveal the effect of DRD2 rs1800497 polymorphism on athletic performance.https://dergipark.org.tr/tr/download/article-file/1669860sportsgeneticspolymorphismdrd2football |
| spellingShingle | Beste Tacal Aslan Özlem Özge Yılmaz Tolga Polat Çisem Şılar Başak Funda Eken Canan Sercan Doğan Korkut Ulucan Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players Türk Spor ve Egzersiz Dergisi sports genetics polymorphism drd2 football |
| title | Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players |
| title_full | Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players |
| title_fullStr | Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players |
| title_full_unstemmed | Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players |
| title_short | Distribution of Dopamine Receptor 2 DRD2 rs1800497 Polymorphisms in Professional Football Players |
| title_sort | distribution of dopamine receptor 2 drd2 rs1800497 polymorphisms in professional football players |
| topic | sports genetics polymorphism drd2 football |
| url | https://dergipark.org.tr/tr/download/article-file/1669860 |
| work_keys_str_mv | AT bestetacalaslan distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT ozlemozgeyılmaz distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT tolgapolat distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT cisemsılar distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT basakfundaeken distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT canansercandogan distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers AT korkutulucan distributionofdopaminereceptor2drd2rs1800497polymorphismsinprofessionalfootballplayers |