Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents
A facile one-pot synthesis of 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazol-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives was synthesized in one pot by condensing various 2-fluoroquinoline-3-carbaldehyde 1a–d, enaminones 2a–c and malononitrile or ethylcynoacetate 3a–b...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610311002699 |
| _version_ | 1818421704386412544 |
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| author | Amish Shah Dilipsinh Raj |
| author_facet | Amish Shah Dilipsinh Raj |
| author_sort | Amish Shah |
| collection | DOAJ |
| description | A facile one-pot synthesis of 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazol-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives was synthesized in one pot by condensing various 2-fluoroquinoline-3-carbaldehyde 1a–d, enaminones 2a–c and malononitrile or ethylcynoacetate 3a–b in ethanol. All the compounds were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis. All the synthesized compounds were screened for their antibacterial activity against Gram positive bacterial species Streptococcus pneumoniae, Bacillus subtilus and Clostridium tetani, Gram negative bacterial species Escherichia coli, Salmonella typhi and Vibrio cholerae and fungicidal activity against Candida albicans and Aspergillus fumigates. |
| first_indexed | 2024-12-14T13:14:35Z |
| format | Article |
| id | doaj.art-a3223a2abe2e455ba223b2cda09d8f08 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-14T13:14:35Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-a3223a2abe2e455ba223b2cda09d8f082022-12-21T23:00:06ZengElsevierJournal of Saudi Chemical Society1319-61032015-01-01191738210.1016/j.jscs.2011.12.021Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agentsAmish ShahDilipsinh RajA facile one-pot synthesis of 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazol-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives was synthesized in one pot by condensing various 2-fluoroquinoline-3-carbaldehyde 1a–d, enaminones 2a–c and malononitrile or ethylcynoacetate 3a–b in ethanol. All the compounds were characterized by IR, 1H NMR, 13C NMR spectra and elemental analysis. All the synthesized compounds were screened for their antibacterial activity against Gram positive bacterial species Streptococcus pneumoniae, Bacillus subtilus and Clostridium tetani, Gram negative bacterial species Escherichia coli, Salmonella typhi and Vibrio cholerae and fungicidal activity against Candida albicans and Aspergillus fumigates.http://www.sciencedirect.com/science/article/pii/S13196103110026992-Fluoroquinoline-3-carbaldehyde2-Amino-4-phenylthiazoleEnaminoneAntimicrobial activityAntifungal activity |
| spellingShingle | Amish Shah Dilipsinh Raj Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents Journal of Saudi Chemical Society 2-Fluoroquinoline-3-carbaldehyde 2-Amino-4-phenylthiazole Enaminone Antimicrobial activity Antifungal activity |
| title | Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents |
| title_full | Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents |
| title_fullStr | Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents |
| title_full_unstemmed | Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents |
| title_short | Synthesis of some new 2′-amino-2-fluoro-5′-oxo-1′-(4-phenylthiazole-2-yl)-1′,4′,5′,6′,7′,8′-hexahydro-3,4′-biquinoline-3′-carbonitrile derivatives and biological evaluation as antimicrobial agents |
| title_sort | synthesis of some new 2 amino 2 fluoro 5 oxo 1 4 phenylthiazole 2 yl 1 4 5 6 7 8 hexahydro 3 4 biquinoline 3 carbonitrile derivatives and biological evaluation as antimicrobial agents |
| topic | 2-Fluoroquinoline-3-carbaldehyde 2-Amino-4-phenylthiazole Enaminone Antimicrobial activity Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610311002699 |
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