Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing
Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve woun...
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MDPI AG
2021-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/8/1939 |
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| author | Jessica Hoff Berit Karl Jana Gerstmeier Uwe Beekmann Lisa Schmölz Friedemann Börner Dana Kralisch Michael Bauer Oliver Werz Dagmar Fischer Stefan Lorkowski Adrian T. Press |
| author_facet | Jessica Hoff Berit Karl Jana Gerstmeier Uwe Beekmann Lisa Schmölz Friedemann Börner Dana Kralisch Michael Bauer Oliver Werz Dagmar Fischer Stefan Lorkowski Adrian T. Press |
| author_sort | Jessica Hoff |
| collection | DOAJ |
| description | Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries. |
| first_indexed | 2024-03-10T08:32:28Z |
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| id | doaj.art-a322a1cbde454ecfae277b2a73f88da2 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T08:32:28Z |
| publishDate | 2021-07-01 |
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| series | Nanomaterials |
| spelling | doaj.art-a322a1cbde454ecfae277b2a73f88da22023-11-22T08:58:04ZengMDPI AGNanomaterials2079-49912021-07-01118193910.3390/nano11081939Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound HealingJessica Hoff0Berit Karl1Jana Gerstmeier2Uwe Beekmann3Lisa Schmölz4Friedemann Börner5Dana Kralisch6Michael Bauer7Oliver Werz8Dagmar Fischer9Stefan Lorkowski10Adrian T. Press11Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyPharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstraße 8, 07743 Jena, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, GermanyPharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstraße 8, 07743 Jena, GermanyInstitut of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 25, 07743 Jena, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, GermanyPharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstraße 8, 07743 Jena, GermanyDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, GermanyPharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstraße 8, 07743 Jena, GermanyInstitut of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Straße 25, 07743 Jena, GermanyDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyInflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries.https://www.mdpi.com/2079-4991/11/8/1939biocompatible nanocellulosewound healingdrug deliverycontrolled releaseinflammationtocopherols |
| spellingShingle | Jessica Hoff Berit Karl Jana Gerstmeier Uwe Beekmann Lisa Schmölz Friedemann Börner Dana Kralisch Michael Bauer Oliver Werz Dagmar Fischer Stefan Lorkowski Adrian T. Press Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing Nanomaterials biocompatible nanocellulose wound healing drug delivery controlled release inflammation tocopherols |
| title | Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing |
| title_full | Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing |
| title_fullStr | Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing |
| title_full_unstemmed | Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing |
| title_short | Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing |
| title_sort | controlled release of the α tocopherol derived metabolite α 13 carboxychromanol from bacterial nanocellulose wound cover improves wound healing |
| topic | biocompatible nanocellulose wound healing drug delivery controlled release inflammation tocopherols |
| url | https://www.mdpi.com/2079-4991/11/8/1939 |
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