The potential role of gut microbiota outer membrane vesicles in colorectal cancer
Colorectal cancer (CRC) is a common malignant digestive tract tumor in colorectal regions. Considerable evidence now shows that the gut microbiota have essential roles in CRC occurrence and development. Most Gram-negative bacteria release outer membrane vesicles (OMVs) via outer membrane blistering,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1270158/full |
| _version_ | 1797634981230542848 |
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| author | Ran Meng Ran Meng Minmin Zeng Ying Ji Xinxiang Huang Min Xu Min Xu |
| author_facet | Ran Meng Ran Meng Minmin Zeng Ying Ji Xinxiang Huang Min Xu Min Xu |
| author_sort | Ran Meng |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignant digestive tract tumor in colorectal regions. Considerable evidence now shows that the gut microbiota have essential roles in CRC occurrence and development. Most Gram-negative bacteria release outer membrane vesicles (OMVs) via outer membrane blistering, which contain specific cargoes which interact with host cells via intercellular communications, host immune regulation, and gut microbiota homeostasis. Studies have also shown that OMVs selectively cluster near tumor cells, thus cancer treatment strategies based on OMVs have attracted considerable research attention. However, little is known about the possible impact of gut microbiota OMVs in CRC pathophysiology. Therefore, in this review, we summarize the research progress on molecular composition and function of OMV, and review the microbial dysbiosis in CRC. We then focus on the potential role of gut microbiota OMVs in CRC. Finally, we examine the clinical potential of OMVs in CRC treatment, and their main advantages and challenges in tumor therapy. |
| first_indexed | 2024-03-11T12:15:57Z |
| format | Article |
| id | doaj.art-a323267e87f64524be088f63b4bcf030 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-11T12:15:57Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a323267e87f64524be088f63b4bcf0302023-11-07T09:34:26ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-11-011410.3389/fmicb.2023.12701581270158The potential role of gut microbiota outer membrane vesicles in colorectal cancerRan Meng0Ran Meng1Minmin Zeng2Ying Ji3Xinxiang Huang4Min Xu5Min Xu6Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Biochemistry and Molecular Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaInstitute of Digestive Diseases, Jiangsu University, Zhenjiang, Jiangsu, ChinaColorectal cancer (CRC) is a common malignant digestive tract tumor in colorectal regions. Considerable evidence now shows that the gut microbiota have essential roles in CRC occurrence and development. Most Gram-negative bacteria release outer membrane vesicles (OMVs) via outer membrane blistering, which contain specific cargoes which interact with host cells via intercellular communications, host immune regulation, and gut microbiota homeostasis. Studies have also shown that OMVs selectively cluster near tumor cells, thus cancer treatment strategies based on OMVs have attracted considerable research attention. However, little is known about the possible impact of gut microbiota OMVs in CRC pathophysiology. Therefore, in this review, we summarize the research progress on molecular composition and function of OMV, and review the microbial dysbiosis in CRC. We then focus on the potential role of gut microbiota OMVs in CRC. Finally, we examine the clinical potential of OMVs in CRC treatment, and their main advantages and challenges in tumor therapy.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1270158/fullcolorectal cancergut microbiotaouter membrane vesiclesgut homeostasisimmune regulation |
| spellingShingle | Ran Meng Ran Meng Minmin Zeng Ying Ji Xinxiang Huang Min Xu Min Xu The potential role of gut microbiota outer membrane vesicles in colorectal cancer Frontiers in Microbiology colorectal cancer gut microbiota outer membrane vesicles gut homeostasis immune regulation |
| title | The potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| title_full | The potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| title_fullStr | The potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| title_full_unstemmed | The potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| title_short | The potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| title_sort | potential role of gut microbiota outer membrane vesicles in colorectal cancer |
| topic | colorectal cancer gut microbiota outer membrane vesicles gut homeostasis immune regulation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1270158/full |
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