Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

Background and aims: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet (HFD)-induced NAFLD, and to explore NRF2 activati...

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Bibliographic Details
Main Authors: Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia, Donna D. Zhang
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
NRF2
KEAP1
High fat diet
Autophagy
Ferroptosis
Liver steatosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003421

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722003421

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