Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function
The gastrointestinal (GI) microbiota has co-evolved with the host in an intricate relationship for mutual benefit, however, inappropriate development of this relationship can have detrimental effects. The developing GI microbiota plays a vital role during the first 1,000 days of postnatal life, duri...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.960492/full |
| _version_ | 1811316823437606912 |
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| author | Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Nicole C. Roy Nicole C. Roy Nicole C. Roy Christine Halliday Christine Halliday Christine Halliday Wayne Young Wayne Young Wayne Young Eric Altermann Eric Altermann Eric Altermann Marlena C. Kruger Ryan N. Dilger Warren C. McNabb Warren C. McNabb |
| author_facet | Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Nicole C. Roy Nicole C. Roy Nicole C. Roy Christine Halliday Christine Halliday Christine Halliday Wayne Young Wayne Young Wayne Young Eric Altermann Eric Altermann Eric Altermann Marlena C. Kruger Ryan N. Dilger Warren C. McNabb Warren C. McNabb |
| author_sort | Jane A. Mullaney |
| collection | DOAJ |
| description | The gastrointestinal (GI) microbiota has co-evolved with the host in an intricate relationship for mutual benefit, however, inappropriate development of this relationship can have detrimental effects. The developing GI microbiota plays a vital role during the first 1,000 days of postnatal life, during which occurs parallel development and maturation of the GI tract, immune system, and brain. Several factors such as mode of delivery, gestational age at birth, exposure to antibiotics, host genetics, and nutrition affect the establishment and resultant composition of the GI microbiota, and therefore play a role in shaping host development. Nutrition during the first 1,000 days is considered to have the most potential in shaping microbiota structure and function, influencing its interactions with the immune system in the GI tract and consequent impact on brain development. The importance of the microbiota-GI-brain (MGB) axis is also increasingly recognized for its importance in these developmental changes. This narrative review focuses on the importance of the GI microbiota and the impact of nutrition on MGB axis during the immune system and brain developmental period in early postnatal life of infants. |
| first_indexed | 2024-04-13T11:56:04Z |
| format | Article |
| id | doaj.art-a32679106e404c9b9963a8e06fa5fe7e |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T11:56:04Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a32679106e404c9b9963a8e06fa5fe7e2022-12-22T02:47:55ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.960492960492Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and functionJane A. Mullaney0Jane A. Mullaney1Jane A. Mullaney2Nicole C. Roy3Nicole C. Roy4Nicole C. Roy5Christine Halliday6Christine Halliday7Christine Halliday8Wayne Young9Wayne Young10Wayne Young11Eric Altermann12Eric Altermann13Eric Altermann14Marlena C. Kruger15Ryan N. Dilger16Warren C. McNabb17Warren C. McNabb18Riddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandDepartment of Human Nutrition, University of Otago, Dunedin, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandSchool of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandSchool of Veterinary Science, Massey University, Palmerston North, New ZealandSchool of Health Sciences, College of Health, Massey University, Palmerston North, New ZealandDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesRiddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandThe gastrointestinal (GI) microbiota has co-evolved with the host in an intricate relationship for mutual benefit, however, inappropriate development of this relationship can have detrimental effects. The developing GI microbiota plays a vital role during the first 1,000 days of postnatal life, during which occurs parallel development and maturation of the GI tract, immune system, and brain. Several factors such as mode of delivery, gestational age at birth, exposure to antibiotics, host genetics, and nutrition affect the establishment and resultant composition of the GI microbiota, and therefore play a role in shaping host development. Nutrition during the first 1,000 days is considered to have the most potential in shaping microbiota structure and function, influencing its interactions with the immune system in the GI tract and consequent impact on brain development. The importance of the microbiota-GI-brain (MGB) axis is also increasingly recognized for its importance in these developmental changes. This narrative review focuses on the importance of the GI microbiota and the impact of nutrition on MGB axis during the immune system and brain developmental period in early postnatal life of infants.https://www.frontiersin.org/articles/10.3389/fmicb.2022.960492/fulldietgastrointestinal microbiotagastrointestinal-brain developmentimmune developmentearly lifemicrobiota-GI-brain axis |
| spellingShingle | Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Nicole C. Roy Nicole C. Roy Nicole C. Roy Christine Halliday Christine Halliday Christine Halliday Wayne Young Wayne Young Wayne Young Eric Altermann Eric Altermann Eric Altermann Marlena C. Kruger Ryan N. Dilger Warren C. McNabb Warren C. McNabb Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function Frontiers in Microbiology diet gastrointestinal microbiota gastrointestinal-brain development immune development early life microbiota-GI-brain axis |
| title | Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| title_full | Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| title_fullStr | Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| title_full_unstemmed | Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| title_short | Effects of early postnatal life nutritional interventions on immune-microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| title_sort | effects of early postnatal life nutritional interventions on immune microbiome interactions in the gastrointestinal tract and implications for brain development and function |
| topic | diet gastrointestinal microbiota gastrointestinal-brain development immune development early life microbiota-GI-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.960492/full |
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