Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

Background We aim to generate a line of “universal donor” human induced pluripotent stem cells (hiPSCs) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. Methods and Results hiPSCs carrying knockout mutations for 2 key components (β2...

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Bibliographic Details
Main Authors: Saidulu Mattapally, Kevin M. Pawlik, Vladimir G. Fast, Esther Zumaquero, Frances E. Lund, Troy D. Randall, Tim M. Townes, Jianyi Zhang
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
3‐dimensional culture
β2 microglobulin
class II major histocompatibility class transactivator
immunology
stem cell
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.010239

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