An Update on mRNA-Based Viral Vaccines
With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. The unprecedently speedy deve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/9/965 |
| _version_ | 1797517032915206144 |
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| author | Subbiah Jeeva Ki-Hye Kim Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang |
| author_facet | Subbiah Jeeva Ki-Hye Kim Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang |
| author_sort | Subbiah Jeeva |
| collection | DOAJ |
| description | With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. Recent updates are briefly described in the status of mRNA vaccines against SARS-CoV-2, influenza virus, and other viral pathogens. Unique features of mRNA vaccine platforms and future perspectives are discussed. |
| first_indexed | 2024-03-10T07:09:51Z |
| format | Article |
| id | doaj.art-a32a5485ee6f4f3cae37db81ddb506cf |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T07:09:51Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a32a5485ee6f4f3cae37db81ddb506cf2023-11-22T15:34:09ZengMDPI AGVaccines2076-393X2021-08-019996510.3390/vaccines9090965An Update on mRNA-Based Viral VaccinesSubbiah Jeeva0Ki-Hye Kim1Chong Hyun Shin2Bao-Zhong Wang3Sang-Moo Kang4Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USACenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USAWith the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic transcription reactions. The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. Recent updates are briefly described in the status of mRNA vaccines against SARS-CoV-2, influenza virus, and other viral pathogens. Unique features of mRNA vaccine platforms and future perspectives are discussed.https://www.mdpi.com/2076-393X/9/9/965mRNA vaccinesSARS-CoV-2influenza |
| spellingShingle | Subbiah Jeeva Ki-Hye Kim Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang An Update on mRNA-Based Viral Vaccines Vaccines mRNA vaccines SARS-CoV-2 influenza |
| title | An Update on mRNA-Based Viral Vaccines |
| title_full | An Update on mRNA-Based Viral Vaccines |
| title_fullStr | An Update on mRNA-Based Viral Vaccines |
| title_full_unstemmed | An Update on mRNA-Based Viral Vaccines |
| title_short | An Update on mRNA-Based Viral Vaccines |
| title_sort | update on mrna based viral vaccines |
| topic | mRNA vaccines SARS-CoV-2 influenza |
| url | https://www.mdpi.com/2076-393X/9/9/965 |
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