Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein

Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein

Aim: To reconstruct the ancestral sequence of human adenoviral hexon protein by combining sequence variations and structural information. And to provide a candidate hexon protein for developing new adenoviral vector capable of escaping the pre-existing immunity in healthy populations.Methods: The se...

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Bibliographic Details
Main Authors: Yingchen Wang, Zhe Zhang, Lei Shang, Hong Gao, Xiqiao Du, Falong Li, Ya Gao, Guiyun Qi, Weiyuan Guo, Zhangyi Qu, Tuo Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
human adenovirus
protein structure
evolutionary trace
common ancestor reconstruction
serum immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.717047/full

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