Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice
Background & Objective: Coriandrum sativum L (CS) has different pharmacological properties such as analgesic, anti-inflammatory, and anti-stress effects. Hence, in the present study the effects of CS essential oil on naloxone -induced jumping in morphine-dependent mice was investigated. Material...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2017-12-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1467-en.pdf |
| _version_ | 1827812380876210176 |
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| author | Shahram Saghaei Saeid Abbasi Maleki |
| author_facet | Shahram Saghaei Saeid Abbasi Maleki |
| author_sort | Shahram Saghaei |
| collection | DOAJ |
| description | Background & Objective: Coriandrum sativum L (CS) has different pharmacological properties such as analgesic, anti-inflammatory, and anti-stress effects. Hence, in the present study the effects of CS essential oil on naloxone -induced jumping in morphine-dependent mice was investigated.
Material & Methods: In this experimental study, 60 male albino mice were used. The animals were divided into 10 groups of 6, including carrier (10 ml/kg), clonidine (3.5 mg/kg), and different doses of CS essential oil (400, 600, and 800 mg/kg). Tolerance and dependency on morphine were induced by administration of different doses of morphine (50, 50, 75, and 50 mg/kg, respectively) in a 4-day schedule. On the last day, after administration of single dose of morphine, Naloxone (5 mg /kg) was injected and the number of jumps was recorded within 30 minutes.
Results: Results showed that all doses of CS essential oil and clonidine, compared to control group, significantly decreased the number of jumping in both tolerance and dependence stage (P<0.001).Also, only high (800mg/kg) and all doses of essential oil reduced the number of jumping during tolerance and dependence stages respectively, better than clonidine .
Conclusion: Based on present study findings, it is concluded that, probably the existing linalool in CS could decrease the number of jumps from tolerance and dependence in morphine- dependent mice. Of course, further studies are required to clarify their exact mechanism of action. |
| first_indexed | 2024-03-11T23:17:47Z |
| format | Article |
| id | doaj.art-a32e3f22dbaa47ceb4ea4be3361a5b58 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:47Z |
| publishDate | 2017-12-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-a32e3f22dbaa47ceb4ea4be3361a5b582023-09-20T21:23:30ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232017-12-0174521529Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent MiceShahram Saghaei0Saeid Abbasi Maleki1 Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran Background & Objective: Coriandrum sativum L (CS) has different pharmacological properties such as analgesic, anti-inflammatory, and anti-stress effects. Hence, in the present study the effects of CS essential oil on naloxone -induced jumping in morphine-dependent mice was investigated. Material & Methods: In this experimental study, 60 male albino mice were used. The animals were divided into 10 groups of 6, including carrier (10 ml/kg), clonidine (3.5 mg/kg), and different doses of CS essential oil (400, 600, and 800 mg/kg). Tolerance and dependency on morphine were induced by administration of different doses of morphine (50, 50, 75, and 50 mg/kg, respectively) in a 4-day schedule. On the last day, after administration of single dose of morphine, Naloxone (5 mg /kg) was injected and the number of jumps was recorded within 30 minutes. Results: Results showed that all doses of CS essential oil and clonidine, compared to control group, significantly decreased the number of jumping in both tolerance and dependence stage (P<0.001).Also, only high (800mg/kg) and all doses of essential oil reduced the number of jumping during tolerance and dependence stages respectively, better than clonidine . Conclusion: Based on present study findings, it is concluded that, probably the existing linalool in CS could decrease the number of jumps from tolerance and dependence in morphine- dependent mice. Of course, further studies are required to clarify their exact mechanism of action.http://jabs.fums.ac.ir/article-1-1467-en.pdfcoriandrum sativum lmorphinenaloxonephysical dependencenumber of jumpsmice |
| spellingShingle | Shahram Saghaei Saeid Abbasi Maleki Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice Journal of Advanced Biomedical Sciences coriandrum sativum l morphine naloxone physical dependence number of jumps mice |
| title | Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice |
| title_full | Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice |
| title_fullStr | Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice |
| title_full_unstemmed | Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice |
| title_short | Evaluation of the Effect of Coriandrum sativum L. Essentisal oil on Naloxone-Induced Jumping in Morphine-Dependent Mice |
| title_sort | evaluation of the effect of coriandrum sativum l essentisal oil on naloxone induced jumping in morphine dependent mice |
| topic | coriandrum sativum l morphine naloxone physical dependence number of jumps mice |
| url | http://jabs.fums.ac.ir/article-1-1467-en.pdf |
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