Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy
Abstract Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine. The Pro12Ala polymorphism in the peroxisome proliferator‐activated receptor‐γ2 gene has...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.13208 |
| _version_ | 1818646424705826816 |
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| author | Yung‐Nien Chen Pei‐Wen Wang Shih‐Chen Tung Ming‐Chun Kuo Shao‐Wen Weng Chen‐Kai Chou Chih‐Min Chang Chia‐Jen Tsa Cheng‐Feng Taso Feng‐Chih Shen Jung‐Fu Chen |
| author_facet | Yung‐Nien Chen Pei‐Wen Wang Shih‐Chen Tung Ming‐Chun Kuo Shao‐Wen Weng Chen‐Kai Chou Chih‐Min Chang Chia‐Jen Tsa Cheng‐Feng Taso Feng‐Chih Shen Jung‐Fu Chen |
| author_sort | Yung‐Nien Chen |
| collection | DOAJ |
| description | Abstract Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine. The Pro12Ala polymorphism in the peroxisome proliferator‐activated receptor‐γ2 gene has been confirmed to improve insulin sensitivity, but its association with susceptibility to DN in patients with type 2 diabetes remains inconclusive. Materials and Methods To examine whether the Pro12Ala polymorphism leads to the development of DN, a case‐control study was carried out in 554 patients with type 2 diabetes. The genotypes of Pro12Ala polymorphism of the peroxisome proliferator‐activated receptor gamma 2 gene were analyzed by real‐time polymerase chain reaction with TaqMan® probe genotyping assay in all patients. Results The mean age of the study population was 57.7 ± 8.8 years, with average diabetes duration of 12.8 ± 6.9 years. The prevalence of albuminuria was 43.5%. The frequency of genotype Pro12Pro, Pro12Ala and Ala12Ala genotype were 92.6%, 7.0%, 0.4% in our study population, and 90.4%, 8.9% and 0.7% in normal urinary albumin‐to‐creatinine ratio group, respectively. The Ala carriers (Pro12Ala + Ala12Ala) had significantly lower urinary albumin‐to‐creatinine ratio (15.0 vs 20.5 mg/g, P = 0.001) and better renal function (estimated glomerular filtration rate 81.8 [69.8–97.6] vs 78.7 mL/min/1.73 m2 [61.6–96.2]; P = 0.05) compared with those with the genotype Pro12Pro. After adjustment for age, sex and other confounders, the odds ratio of albuminuria for the Ala12 allele was 0.428 (95% confidence interval 0.195–0.940, P = 0.034]). Conclusions Our results suggest that the peroxisome proliferator‐activated receptor gamma 2 Ala12 variant has significant protective effects against albuminuria and DN. |
| first_indexed | 2024-12-17T00:46:25Z |
| format | Article |
| id | doaj.art-a32eefb43199483d85c42086411cd124 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-17T00:46:25Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-a32eefb43199483d85c42086411cd1242022-12-21T22:09:53ZengWileyJournal of Diabetes Investigation2040-11162040-11242020-07-0111492392910.1111/jdi.13208Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathyYung‐Nien Chen0Pei‐Wen Wang1Shih‐Chen Tung2Ming‐Chun Kuo3Shao‐Wen Weng4Chen‐Kai Chou5Chih‐Min Chang6Chia‐Jen Tsa7Cheng‐Feng Taso8Feng‐Chih Shen9Jung‐Fu Chen10Division of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanDivision of Metabolism and Endocrinology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung TaiwanAbstract Aims/Introduction Diabetic nephropathy (DN) is a complication of diabetes mellitus that is characterized by the gradual loss of kidney function, which results in increased levels of albumin in the urine. The Pro12Ala polymorphism in the peroxisome proliferator‐activated receptor‐γ2 gene has been confirmed to improve insulin sensitivity, but its association with susceptibility to DN in patients with type 2 diabetes remains inconclusive. Materials and Methods To examine whether the Pro12Ala polymorphism leads to the development of DN, a case‐control study was carried out in 554 patients with type 2 diabetes. The genotypes of Pro12Ala polymorphism of the peroxisome proliferator‐activated receptor gamma 2 gene were analyzed by real‐time polymerase chain reaction with TaqMan® probe genotyping assay in all patients. Results The mean age of the study population was 57.7 ± 8.8 years, with average diabetes duration of 12.8 ± 6.9 years. The prevalence of albuminuria was 43.5%. The frequency of genotype Pro12Pro, Pro12Ala and Ala12Ala genotype were 92.6%, 7.0%, 0.4% in our study population, and 90.4%, 8.9% and 0.7% in normal urinary albumin‐to‐creatinine ratio group, respectively. The Ala carriers (Pro12Ala + Ala12Ala) had significantly lower urinary albumin‐to‐creatinine ratio (15.0 vs 20.5 mg/g, P = 0.001) and better renal function (estimated glomerular filtration rate 81.8 [69.8–97.6] vs 78.7 mL/min/1.73 m2 [61.6–96.2]; P = 0.05) compared with those with the genotype Pro12Pro. After adjustment for age, sex and other confounders, the odds ratio of albuminuria for the Ala12 allele was 0.428 (95% confidence interval 0.195–0.940, P = 0.034]). Conclusions Our results suggest that the peroxisome proliferator‐activated receptor gamma 2 Ala12 variant has significant protective effects against albuminuria and DN.https://doi.org/10.1111/jdi.13208Diabetic nephropathiesPeroxisome proliferator‐activated receptor gammaPolymorphism |
| spellingShingle | Yung‐Nien Chen Pei‐Wen Wang Shih‐Chen Tung Ming‐Chun Kuo Shao‐Wen Weng Chen‐Kai Chou Chih‐Min Chang Chia‐Jen Tsa Cheng‐Feng Taso Feng‐Chih Shen Jung‐Fu Chen Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy Journal of Diabetes Investigation Diabetic nephropathies Peroxisome proliferator‐activated receptor gamma Polymorphism |
| title | Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| title_full | Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| title_fullStr | Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| title_full_unstemmed | Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| title_short | Association between Pro12Ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| title_sort | association between pro12ala polymorphism and albuminuria in type 2 diabetic nephropathy |
| topic | Diabetic nephropathies Peroxisome proliferator‐activated receptor gamma Polymorphism |
| url | https://doi.org/10.1111/jdi.13208 |
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