Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases
OBJECTIVE: The objective of this retrospective study was to assess the efficacy of medical thoracoscopy in diagnosing of tuberculous pleurisy and characterize tuberculous pleurisy with medical thoracoscopy. METHODS: A total of 575 patients with tuberculous pleurisy who underwent medical thoracoscopy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2019;volume=14;issue=2;spage=134;epage=140;aulast=Zhao |
| _version_ | 1818436086646439936 |
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| author | Tingting Zhao Yurong Xu Qian Song Xinjie Wang Minghua Jin Dianjie Lin |
| author_facet | Tingting Zhao Yurong Xu Qian Song Xinjie Wang Minghua Jin Dianjie Lin |
| author_sort | Tingting Zhao |
| collection | DOAJ |
| description | OBJECTIVE: The objective of this retrospective study was to assess the efficacy of medical thoracoscopy in diagnosing of tuberculous pleurisy and characterize tuberculous pleurisy with medical thoracoscopy.
METHODS: A total of 575 patients with tuberculous pleurisy who underwent medical thoracoscopy were included in the study. Demographic data, clinical manifestations, and routine and biochemical tests on pleural fluid, cultures of pleural fluid, sputum, and pleural biopsy for the detection of Mycobacterium tuberculosis and pathological findings were evaluated.
RESULTS: Sputum, pleural fluid, and pleural biopsy cultures were positive for M. tuberculosis in 12.5%, 19.2%, and 41.9% of patients, respectively. Furthermore, there were significant differences in total positive tuberculosis (TB) tests in the pleural cavity according to patient's age (<18 years old, 50.0%; 18–34 years old, 50.2%; 35–59 years old, 34.8%; >60 years old, 18.6%; and all groups vs. >60 years old, P < 0.001). Patients with 18–34 years old were more likely to have granuloma in pleural biopsy specimens when compared to patients >60 years old (77.0% vs. 37.9%). The percentage of patients with high adenosine deaminase (ADA) levels in pleural fluid (>40 U/L), who were <18, 18–34, 35–59, and > 60 years old, was 83.3% (15/18), 72.8% (193/265), 51.2% (88/172), and 34.7% (17/49), respectively (all groups vs. >60 years old, P < 0.001).
CONCLUSION: Medical thoracoscopy is effective for diagnosing tuberculous pleurisy. Younger patients with tuberculous pleurisy have a higher number of positive TB tests in the pleural cavity, are more likely to have granuloma in pleural biopsy specimens, and have higher ADA levels in the pleural fluid. |
| first_indexed | 2024-12-14T17:03:11Z |
| format | Article |
| id | doaj.art-a3307ef57707443db638426ef9eb4186 |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-12-14T17:03:11Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-a3307ef57707443db638426ef9eb41862022-12-21T22:53:48ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572019-01-0114213414010.4103/atm.ATM_359_18Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 casesTingting ZhaoYurong XuQian SongXinjie WangMinghua JinDianjie LinOBJECTIVE: The objective of this retrospective study was to assess the efficacy of medical thoracoscopy in diagnosing of tuberculous pleurisy and characterize tuberculous pleurisy with medical thoracoscopy. METHODS: A total of 575 patients with tuberculous pleurisy who underwent medical thoracoscopy were included in the study. Demographic data, clinical manifestations, and routine and biochemical tests on pleural fluid, cultures of pleural fluid, sputum, and pleural biopsy for the detection of Mycobacterium tuberculosis and pathological findings were evaluated. RESULTS: Sputum, pleural fluid, and pleural biopsy cultures were positive for M. tuberculosis in 12.5%, 19.2%, and 41.9% of patients, respectively. Furthermore, there were significant differences in total positive tuberculosis (TB) tests in the pleural cavity according to patient's age (<18 years old, 50.0%; 18–34 years old, 50.2%; 35–59 years old, 34.8%; >60 years old, 18.6%; and all groups vs. >60 years old, P < 0.001). Patients with 18–34 years old were more likely to have granuloma in pleural biopsy specimens when compared to patients >60 years old (77.0% vs. 37.9%). The percentage of patients with high adenosine deaminase (ADA) levels in pleural fluid (>40 U/L), who were <18, 18–34, 35–59, and > 60 years old, was 83.3% (15/18), 72.8% (193/265), 51.2% (88/172), and 34.7% (17/49), respectively (all groups vs. >60 years old, P < 0.001). CONCLUSION: Medical thoracoscopy is effective for diagnosing tuberculous pleurisy. Younger patients with tuberculous pleurisy have a higher number of positive TB tests in the pleural cavity, are more likely to have granuloma in pleural biopsy specimens, and have higher ADA levels in the pleural fluid.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2019;volume=14;issue=2;spage=134;epage=140;aulast=ZhaoAdenosine deaminasethoracoscopytuberculous granulomatuberculous pleurisy |
| spellingShingle | Tingting Zhao Yurong Xu Qian Song Xinjie Wang Minghua Jin Dianjie Lin Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases Annals of Thoracic Medicine Adenosine deaminase thoracoscopy tuberculous granuloma tuberculous pleurisy |
| title | Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases |
| title_full | Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases |
| title_fullStr | Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases |
| title_full_unstemmed | Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases |
| title_short | Medical thoracoscopy for tuberculous pleurisy: A retrospective analysis of 575 cases |
| title_sort | medical thoracoscopy for tuberculous pleurisy a retrospective analysis of 575 cases |
| topic | Adenosine deaminase thoracoscopy tuberculous granuloma tuberculous pleurisy |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2019;volume=14;issue=2;spage=134;epage=140;aulast=Zhao |
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