Dual-acting antibacterial porous chitosan film embedded with a photosensitizer
This study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectious wounds. The Cs/small molecular compound (Cs-cpd...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Science and Technology of Advanced Materials |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14686996.2020.1795431 |
| _version_ | 1818940419390570496 |
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| author | Zi-Jun Liu Shu-Ching Lin Pei-Yuan Lee Ying-Ting Lin Zi-Lun Lai Cheng-Chung Chang Gou-Jen Wang |
| author_facet | Zi-Jun Liu Shu-Ching Lin Pei-Yuan Lee Ying-Ting Lin Zi-Lun Lai Cheng-Chung Chang Gou-Jen Wang |
| author_sort | Zi-Jun Liu |
| collection | DOAJ |
| description | This study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectious wounds. The Cs/small molecular compound (Cs-cpd.2) dressing was prepared using the freeze-drying method. Characterization of the synthesized Cs-cpd.2 indicated that it has high porosity and moisture absorption effect, hence enhancing the absorption of wound exudate. Experimental results showed that Cs-cpd.2 dressing has good bactericidal and bacteriostatic effects on Staphylococcus aureus under visible-light irradiation and has antibacterial effect in the dark. It was also found that the small molecular compound does not have cytotoxicity at a dose of 0–5 μM. Furthermore, Cs-cpd.2 that contained small molecular compound with a concentration of 0.3–1 μM has positive effect on both the cell viability rate and cell proliferation rate of human fibroblast CG1639. Cs-cpd.2 can significantly promote cell proliferation when the small molecular compound and the basic fibroblast growth factor bFGF were added together. Therefore, the proposed Cs-cpd.2 dressing is feasible for photodynamic therapy (PDT) and clinical wound dressing applications. |
| first_indexed | 2024-12-20T06:39:21Z |
| format | Article |
| id | doaj.art-a332d9b0ff5f4beb94fedc9acdcf43a5 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-12-20T06:39:21Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-a332d9b0ff5f4beb94fedc9acdcf43a52022-12-21T19:49:55ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142020-01-0121156257210.1080/14686996.2020.17954311795431Dual-acting antibacterial porous chitosan film embedded with a photosensitizerZi-Jun Liu0Shu-Ching Lin1Pei-Yuan Lee2Ying-Ting Lin3Zi-Lun Lai4Cheng-Chung Chang5Gou-Jen Wang6Graduate Institute of Biomedical Engineering, National Chung-Hsing UniversityGraduate Institute of Biomedical Engineering, National Chung-Hsing UniversityGraduate Institute of Biomedical Engineering, National Chung-Hsing UniversityProgram in Tissue Engineering and Regenerative Medicine, National Chung-Hsing UniversityGraduate Institute of Biomedical Engineering, National Chung-Hsing UniversityGraduate Institute of Biomedical Engineering, National Chung-Hsing UniversityGraduate Institute of Biomedical Engineering, National Chung-Hsing UniversityThis study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectious wounds. The Cs/small molecular compound (Cs-cpd.2) dressing was prepared using the freeze-drying method. Characterization of the synthesized Cs-cpd.2 indicated that it has high porosity and moisture absorption effect, hence enhancing the absorption of wound exudate. Experimental results showed that Cs-cpd.2 dressing has good bactericidal and bacteriostatic effects on Staphylococcus aureus under visible-light irradiation and has antibacterial effect in the dark. It was also found that the small molecular compound does not have cytotoxicity at a dose of 0–5 μM. Furthermore, Cs-cpd.2 that contained small molecular compound with a concentration of 0.3–1 μM has positive effect on both the cell viability rate and cell proliferation rate of human fibroblast CG1639. Cs-cpd.2 can significantly promote cell proliferation when the small molecular compound and the basic fibroblast growth factor bFGF were added together. Therefore, the proposed Cs-cpd.2 dressing is feasible for photodynamic therapy (PDT) and clinical wound dressing applications.http://dx.doi.org/10.1080/14686996.2020.1795431dual-acting antibacterial filmporous chitosan/small molecular compoundbactericidal and bacteriostatic effects |
| spellingShingle | Zi-Jun Liu Shu-Ching Lin Pei-Yuan Lee Ying-Ting Lin Zi-Lun Lai Cheng-Chung Chang Gou-Jen Wang Dual-acting antibacterial porous chitosan film embedded with a photosensitizer Science and Technology of Advanced Materials dual-acting antibacterial film porous chitosan/small molecular compound bactericidal and bacteriostatic effects |
| title | Dual-acting antibacterial porous chitosan film embedded with a photosensitizer |
| title_full | Dual-acting antibacterial porous chitosan film embedded with a photosensitizer |
| title_fullStr | Dual-acting antibacterial porous chitosan film embedded with a photosensitizer |
| title_full_unstemmed | Dual-acting antibacterial porous chitosan film embedded with a photosensitizer |
| title_short | Dual-acting antibacterial porous chitosan film embedded with a photosensitizer |
| title_sort | dual acting antibacterial porous chitosan film embedded with a photosensitizer |
| topic | dual-acting antibacterial film porous chitosan/small molecular compound bactericidal and bacteriostatic effects |
| url | http://dx.doi.org/10.1080/14686996.2020.1795431 |
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