Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis
Without using any toxic or hazardous reagent, ligand, acid, transition metal catalyst, additives/promoters and organic solvent, green Knoevenagel condensation and tandem Knoevenagel–Michael reactions have been successfully carried out by using chickpea leaf exudates as a naturally sourced Bronsted a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2018-01-01
|
| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170333 |
| _version_ | 1818134697627090944 |
|---|---|
| author | Snehali Mali Sachin Shinde Shashikant Damte Suresh Patil |
| author_facet | Snehali Mali Sachin Shinde Shashikant Damte Suresh Patil |
| author_sort | Snehali Mali |
| collection | DOAJ |
| description | Without using any toxic or hazardous reagent, ligand, acid, transition metal catalyst, additives/promoters and organic solvent, green Knoevenagel condensation and tandem Knoevenagel–Michael reactions have been successfully carried out by using chickpea leaf exudates as a naturally sourced Bronsted acid type bio-catalyst. The reaction proceeds in neat chickpea leaf exudates at room temperature in aqueous conditions in very short reaction times, and therefore, it is an evergreen and environmentally sound alternative to the existing protocols for benzopyran synthesis. In comparison to the conventional methods, this synthetic pathway complies with several key requirements of green chemistry principles such as the utilization of biodegradable catalyst obtained from renewable feedstock, auxiliary aqueous conditions, along with waste prevention. The same protocol was also extended to the synthesis of 2H-xanthene-1,8-diones by condensation of aromatic aldehydes with dimedone achieving excellent yields. Thus, the reported protocol offers an attractive option because of its ecological safety, environmental acceptance, sustainability, low-cost straightforward work-up procedure and with excellent values of green chemistry metrics as compared with other reported methods. |
| first_indexed | 2024-12-11T09:12:44Z |
| format | Article |
| id | doaj.art-a333631a0f6a42e8910817a30e430b20 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-11T09:12:44Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-a333631a0f6a42e8910817a30e430b202022-12-22T01:13:27ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015210.1098/rsos.170333170333Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesisSnehali MaliSachin ShindeShashikant DamteSuresh PatilWithout using any toxic or hazardous reagent, ligand, acid, transition metal catalyst, additives/promoters and organic solvent, green Knoevenagel condensation and tandem Knoevenagel–Michael reactions have been successfully carried out by using chickpea leaf exudates as a naturally sourced Bronsted acid type bio-catalyst. The reaction proceeds in neat chickpea leaf exudates at room temperature in aqueous conditions in very short reaction times, and therefore, it is an evergreen and environmentally sound alternative to the existing protocols for benzopyran synthesis. In comparison to the conventional methods, this synthetic pathway complies with several key requirements of green chemistry principles such as the utilization of biodegradable catalyst obtained from renewable feedstock, auxiliary aqueous conditions, along with waste prevention. The same protocol was also extended to the synthesis of 2H-xanthene-1,8-diones by condensation of aromatic aldehydes with dimedone achieving excellent yields. Thus, the reported protocol offers an attractive option because of its ecological safety, environmental acceptance, sustainability, low-cost straightforward work-up procedure and with excellent values of green chemistry metrics as compared with other reported methods.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170333benzopyrancicer arietinumchickpea exudatesbio-catalystnatural catalyst |
| spellingShingle | Snehali Mali Sachin Shinde Shashikant Damte Suresh Patil Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis Royal Society Open Science benzopyran cicer arietinum chickpea exudates bio-catalyst natural catalyst |
| title | Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis |
| title_full | Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis |
| title_fullStr | Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis |
| title_full_unstemmed | Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis |
| title_short | Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis |
| title_sort | synergistic effect of natural chickpea leaf exudates acids in heterocyclization a greener protocol for benzopyran synthesis |
| topic | benzopyran cicer arietinum chickpea exudates bio-catalyst natural catalyst |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.170333 |
| work_keys_str_mv | AT snehalimali synergisticeffectofnaturalchickpealeafexudatesacidsinheterocyclizationagreenerprotocolforbenzopyransynthesis AT sachinshinde synergisticeffectofnaturalchickpealeafexudatesacidsinheterocyclizationagreenerprotocolforbenzopyransynthesis AT shashikantdamte synergisticeffectofnaturalchickpealeafexudatesacidsinheterocyclizationagreenerprotocolforbenzopyransynthesis AT sureshpatil synergisticeffectofnaturalchickpealeafexudatesacidsinheterocyclizationagreenerprotocolforbenzopyransynthesis |