SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex
Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD, schizophrenia, and bipolar disorder.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03891-y |
| _version_ | 1828735448609980416 |
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| author | Minoru Hatayama Kei-ichi Katayama Yukie Kawahara Hayato Matsunaga Noriko Takashima Yoshimi Iwayama Yoshifumi Matsumoto Akinori Nishi Takeo Yoshikawa Jun Aruga |
| author_facet | Minoru Hatayama Kei-ichi Katayama Yukie Kawahara Hayato Matsunaga Noriko Takashima Yoshimi Iwayama Yoshifumi Matsumoto Akinori Nishi Takeo Yoshikawa Jun Aruga |
| author_sort | Minoru Hatayama |
| collection | DOAJ |
| description | Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD, schizophrenia, and bipolar disorder. |
| first_indexed | 2024-04-12T23:07:30Z |
| format | Article |
| id | doaj.art-a336a2a8d47249c0ba8e7d324f5d1a23 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-12T23:07:30Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a336a2a8d47249c0ba8e7d324f5d1a232022-12-22T03:12:54ZengNature PortfolioCommunications Biology2399-36422022-09-015111810.1038/s42003-022-03891-ySLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortexMinoru Hatayama0Kei-ichi Katayama1Yukie Kawahara2Hayato Matsunaga3Noriko Takashima4Yoshimi Iwayama5Yoshifumi Matsumoto6Akinori Nishi7Takeo Yoshikawa8Jun Aruga9Department of Medical Pharmacology, Nagasaki University Institute of Biomedical SciencesLaboratory for Behavioral and Developmental Disorders, RIKEN Brain Science InstituteDepartment of Pharmacology, Kurume University School of MedicineDepartment of Medical Pharmacology, Nagasaki University Institute of Biomedical SciencesLaboratory for Behavioral and Developmental Disorders, RIKEN Brain Science InstituteLaboratory for Molecular Psychiatry, RIKEN Brain Science InstituteLaboratory for Behavioral and Developmental Disorders, RIKEN Brain Science InstituteDepartment of Pharmacology, Kurume University School of MedicineLaboratory for Molecular Psychiatry, RIKEN Brain Science InstituteDepartment of Medical Pharmacology, Nagasaki University Institute of Biomedical SciencesLoss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD, schizophrenia, and bipolar disorder.https://doi.org/10.1038/s42003-022-03891-y |
| spellingShingle | Minoru Hatayama Kei-ichi Katayama Yukie Kawahara Hayato Matsunaga Noriko Takashima Yoshimi Iwayama Yoshifumi Matsumoto Akinori Nishi Takeo Yoshikawa Jun Aruga SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex Communications Biology |
| title | SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| title_full | SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| title_fullStr | SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| title_full_unstemmed | SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| title_short | SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| title_sort | slitrk1 mediated noradrenergic projection suppression in the neonatal prefrontal cortex |
| url | https://doi.org/10.1038/s42003-022-03891-y |
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