SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex

SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex

Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD, schizophrenia, and bipolar disorder.

Bibliographic Details
Main Authors: Minoru Hatayama, Kei-ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03891-y

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