Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study
The present study reports the synthesis and spectroscopic characterization of dinuclear silver(I) complexes, {[Ag(X-O)(phtz-N)]2(µ-phtz-N,N')2} (X = NO3 - (Ag1) and CF3SO3 - (Ag2), and phtz is phthalazine). The interaction of these two complexes with calf thymus DNA (ct-DNA) and bovine serum al...
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| Format: | Article |
| Language: | English |
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University of Kragujevac, Faculty of Science
2023-01-01
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| Series: | Kragujevac Journal of Science |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345079A.pdf |
| _version_ | 1797743734327083008 |
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| author | Ašanin Darko P. Andrejević Tina P. Milivojević Dušan Stevanović Nevena Lj. Glišić Biljana Đ. |
| author_facet | Ašanin Darko P. Andrejević Tina P. Milivojević Dušan Stevanović Nevena Lj. Glišić Biljana Đ. |
| author_sort | Ašanin Darko P. |
| collection | DOAJ |
| description | The present study reports the synthesis and spectroscopic characterization of dinuclear silver(I) complexes, {[Ag(X-O)(phtz-N)]2(µ-phtz-N,N')2} (X = NO3 - (Ag1) and CF3SO3 - (Ag2), and phtz is phthalazine). The interaction of these two complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was investigated to assess their binding affinity to these biomolecules. The binding constants of complexes Ag1 and Ag2 to BSA are found to be higher than those for ct-DNA, being in accordance with their higher affinity toward the studied protein. The values of partition coefficient (logP) for the investigated complexes indicate higher cellular uptake efficiency of Ag1 than Ag2. The in vivo toxicity of the complexes Ag1 and Ag2 against the model organism, Caenorhabditis elegans, was studied to check their therapeutic potential. |
| first_indexed | 2024-03-12T14:59:41Z |
| format | Article |
| id | doaj.art-a337332f551b45f4a552e0c420423af1 |
| institution | Directory Open Access Journal |
| issn | 1450-9636 2466-5509 |
| language | English |
| last_indexed | 2024-03-12T14:59:41Z |
| publishDate | 2023-01-01 |
| publisher | University of Kragujevac, Faculty of Science |
| record_format | Article |
| series | Kragujevac Journal of Science |
| spelling | doaj.art-a337332f551b45f4a552e0c420423af12023-08-14T09:28:40ZengUniversity of Kragujevac, Faculty of ScienceKragujevac Journal of Science1450-96362466-55092023-01-0120234579911450-96362345079ADinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity studyAšanin Darko P.0https://orcid.org/0000-0003-1098-400XAndrejević Tina P.1Milivojević Dušan2https://orcid.org/0000-0001-8924-2679Stevanović Nevena Lj.3Glišić Biljana Đ.4https://orcid.org/0000-0002-6343-8611University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Chemistry, Kragujevac, SerbiaUniversity of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Chemistry, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Science, Department of Chemistry, Kragujevac, SerbiaThe present study reports the synthesis and spectroscopic characterization of dinuclear silver(I) complexes, {[Ag(X-O)(phtz-N)]2(µ-phtz-N,N')2} (X = NO3 - (Ag1) and CF3SO3 - (Ag2), and phtz is phthalazine). The interaction of these two complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was investigated to assess their binding affinity to these biomolecules. The binding constants of complexes Ag1 and Ag2 to BSA are found to be higher than those for ct-DNA, being in accordance with their higher affinity toward the studied protein. The values of partition coefficient (logP) for the investigated complexes indicate higher cellular uptake efficiency of Ag1 than Ag2. The in vivo toxicity of the complexes Ag1 and Ag2 against the model organism, Caenorhabditis elegans, was studied to check their therapeutic potential.https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345079A.pdfsilver(i) complexesphthalazinecaenorhabditis elegansdna interactionprotein interaction 80 |
| spellingShingle | Ašanin Darko P. Andrejević Tina P. Milivojević Dušan Stevanović Nevena Lj. Glišić Biljana Đ. Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study Kragujevac Journal of Science silver(i) complexes phthalazine caenorhabditis elegans dna interaction protein interaction 80 |
| title | Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study |
| title_full | Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study |
| title_fullStr | Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study |
| title_full_unstemmed | Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study |
| title_short | Dinuclear silver(I) complexes with phthalazine: DNA/BSA binding and in vivo toxicity study |
| title_sort | dinuclear silver i complexes with phthalazine dna bsa binding and in vivo toxicity study |
| topic | silver(i) complexes phthalazine caenorhabditis elegans dna interaction protein interaction 80 |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2023/1450-96362345079A.pdf |
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