Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index
Aims: The present study aimed to clarify the relationships between diabetic family history (FH), and dysglycemic response to the oral glucose tolerance test (OGTT), insulin secretion, and insulin sensitivity in young Japanese persons with normal glucose tolerance (NGT). Methods: We measured plasma g...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936822000342 |
| _version_ | 1828105356106006528 |
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| author | Norimitsu Murai Naoko Saito Sayuri Nii Yuto Nishikawa Asami Suzuki Eriko Kodama Tatsuya Iida Kentaro Mikura Hideyuki Imai Mai Hashizume Yasuyoshi Kigawa Rie Tadokoro Chiho Sugisawa Kei Endo Toru Iizaka Fumiko Otsuka Shun Ishibashi Shoichiro Nagasaka |
| author_facet | Norimitsu Murai Naoko Saito Sayuri Nii Yuto Nishikawa Asami Suzuki Eriko Kodama Tatsuya Iida Kentaro Mikura Hideyuki Imai Mai Hashizume Yasuyoshi Kigawa Rie Tadokoro Chiho Sugisawa Kei Endo Toru Iizaka Fumiko Otsuka Shun Ishibashi Shoichiro Nagasaka |
| author_sort | Norimitsu Murai |
| collection | DOAJ |
| description | Aims: The present study aimed to clarify the relationships between diabetic family history (FH), and dysglycemic response to the oral glucose tolerance test (OGTT), insulin secretion, and insulin sensitivity in young Japanese persons with normal glucose tolerance (NGT). Methods: We measured plasma glucose (PG) and immunoreactive insulin levels in 1,309 young Japanese persons (age <40 years) with NGT before and at 30, 60, and 120 min during a 75-g OGTT. Dysglycemia during OGTT was analyzed by k-means clustering analysis. Body mass index (BMI), blood pressure (BP), and lipids were measured. Insulin secretion and sensitivity indices were calculated. Results: PG levels during OGTT were classified by k-means clustering analysis into three groups with stepwise decreases in glucose tolerance even among individuals with NGT. In these clusters, proportion of males, BMI, BP and frequency of FH were higher, and lipid levels were worse, together with decreasing glucose tolerance. Subjects with a diabetic FH showed increases in PG after glucose loading and decreases in insulinogenic index and Matsuda index. Conclusions: Dysglycemic response to OGTT by k-means clustering analysis was associated with FH in young Japanese persons with NGT. FH was also associated with post-loading glucose, insulinogenic index, and Matsuda index. |
| first_indexed | 2024-04-11T10:01:58Z |
| format | Article |
| id | doaj.art-a337aed0c1fb40b79fb4461dd5a0ac4f |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-04-11T10:01:58Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-a337aed0c1fb40b79fb4461dd5a0ac4f2022-12-22T04:30:23ZengElsevierMetabolism Open2589-93682022-09-0115100196Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda indexNorimitsu Murai0Naoko Saito1Sayuri Nii2Yuto Nishikawa3Asami Suzuki4Eriko Kodama5Tatsuya Iida6Kentaro Mikura7Hideyuki Imai8Mai Hashizume9Yasuyoshi Kigawa10Rie Tadokoro11Chiho Sugisawa12Kei Endo13Toru Iizaka14Fumiko Otsuka15Shun Ishibashi16Shoichiro Nagasaka17Division of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, Japan; Corresponding author. Tel.: +81 45 971 1151; Fax: +81 45 973 1019.Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Tochigi, 329-0498, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, JapanDivision of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Tochigi, 329-0498, JapanDivision of Diabetes, Metabolism and Endocrinology, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa, 227-8501, Japan; Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, Tochigi, 329-0498, JapanAims: The present study aimed to clarify the relationships between diabetic family history (FH), and dysglycemic response to the oral glucose tolerance test (OGTT), insulin secretion, and insulin sensitivity in young Japanese persons with normal glucose tolerance (NGT). Methods: We measured plasma glucose (PG) and immunoreactive insulin levels in 1,309 young Japanese persons (age <40 years) with NGT before and at 30, 60, and 120 min during a 75-g OGTT. Dysglycemia during OGTT was analyzed by k-means clustering analysis. Body mass index (BMI), blood pressure (BP), and lipids were measured. Insulin secretion and sensitivity indices were calculated. Results: PG levels during OGTT were classified by k-means clustering analysis into three groups with stepwise decreases in glucose tolerance even among individuals with NGT. In these clusters, proportion of males, BMI, BP and frequency of FH were higher, and lipid levels were worse, together with decreasing glucose tolerance. Subjects with a diabetic FH showed increases in PG after glucose loading and decreases in insulinogenic index and Matsuda index. Conclusions: Dysglycemic response to OGTT by k-means clustering analysis was associated with FH in young Japanese persons with NGT. FH was also associated with post-loading glucose, insulinogenic index, and Matsuda index.http://www.sciencedirect.com/science/article/pii/S2589936822000342Oral glucose tolerance testNormal glucose toleranceInsulinogenic indexMatsuda indexK-means clustering |
| spellingShingle | Norimitsu Murai Naoko Saito Sayuri Nii Yuto Nishikawa Asami Suzuki Eriko Kodama Tatsuya Iida Kentaro Mikura Hideyuki Imai Mai Hashizume Yasuyoshi Kigawa Rie Tadokoro Chiho Sugisawa Kei Endo Toru Iizaka Fumiko Otsuka Shun Ishibashi Shoichiro Nagasaka Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index Metabolism Open Oral glucose tolerance test Normal glucose tolerance Insulinogenic index Matsuda index K-means clustering |
| title | Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index |
| title_full | Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index |
| title_fullStr | Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index |
| title_full_unstemmed | Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index |
| title_short | Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index |
| title_sort | diabetic family history in young japanese persons with normal glucose tolerance associates with k means clustering of glucose response to oral glucose load insulinogenic index and matsuda index |
| topic | Oral glucose tolerance test Normal glucose tolerance Insulinogenic index Matsuda index K-means clustering |
| url | http://www.sciencedirect.com/science/article/pii/S2589936822000342 |
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