Status epilepticus in patients with genetic generalized epilepsy: a case series study
Abstract Background Genetic generalized epilepsy (GGE) accounts for nearly one-third of all epilepsies. The feature of status epilepticus (SE) in patients with GGE has been rarely studied. We aimed to determine the electroclinical characteristics of SE in patients with GGE. Methods In this retrospec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Acta Epileptologica |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42494-023-00144-1 |
| _version_ | 1827581306370785280 |
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| author | Gengyao Hu Bi Wang Beibei Chen Zezhi Wang Ze Chen Yonghong Liu |
| author_facet | Gengyao Hu Bi Wang Beibei Chen Zezhi Wang Ze Chen Yonghong Liu |
| author_sort | Gengyao Hu |
| collection | DOAJ |
| description | Abstract Background Genetic generalized epilepsy (GGE) accounts for nearly one-third of all epilepsies. The feature of status epilepticus (SE) in patients with GGE has been rarely studied. We aimed to determine the electroclinical characteristics of SE in patients with GGE. Methods In this retrospective study, nine patients with GGE were enrolled at Xijing Hospital, Xi’an, China from May 2014 to May 2020. SE was confirmed by 24-h video-EEG recording. The demography, clinical manifestation, brain MRI and SE pattern were analyzed. Results Of the nine patients in the study, seven were female. The mean age of the patients at the time of inclusion was 16.8 years (range 7–31 years), and the mean age at the onset of epilepsy was 10.9 years (range 6–17 years). The follow-up time ranged from 3 months to 6 years. Myoclonic absence status was identified in four patients showing eyelid myoclonia with absence and one patient showing perioral myoclonia with absences. Myoclonic SE was identified in three patients showing juvenile myoclonic epilepsy. Autonomic SE was found in one patient with eyelid myoclonia with absence. SE was terminated by oral midazolam in four patients. In the other five patients, SE terminated spontaneously. Conclusions The seizure type of SE in patients with GGE is often consistent with their major symptoms. Oral midazolam may be an option to terminate SE in patients with GGE. |
| first_indexed | 2024-03-08T22:34:30Z |
| format | Article |
| id | doaj.art-a337dfee8f7d43a58d0a4439fd6f79fa |
| institution | Directory Open Access Journal |
| issn | 2524-4434 |
| language | English |
| last_indexed | 2024-03-08T22:34:30Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Epileptologica |
| spelling | doaj.art-a337dfee8f7d43a58d0a4439fd6f79fa2023-12-17T12:33:19ZengBMCActa Epileptologica2524-44342023-12-01511710.1186/s42494-023-00144-1Status epilepticus in patients with genetic generalized epilepsy: a case series studyGengyao Hu0Bi Wang1Beibei Chen2Zezhi Wang3Ze Chen4Yonghong Liu5Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Department of Neurology, Xijing hospital, Fourth Military Medical University (Air Force Medical University)Abstract Background Genetic generalized epilepsy (GGE) accounts for nearly one-third of all epilepsies. The feature of status epilepticus (SE) in patients with GGE has been rarely studied. We aimed to determine the electroclinical characteristics of SE in patients with GGE. Methods In this retrospective study, nine patients with GGE were enrolled at Xijing Hospital, Xi’an, China from May 2014 to May 2020. SE was confirmed by 24-h video-EEG recording. The demography, clinical manifestation, brain MRI and SE pattern were analyzed. Results Of the nine patients in the study, seven were female. The mean age of the patients at the time of inclusion was 16.8 years (range 7–31 years), and the mean age at the onset of epilepsy was 10.9 years (range 6–17 years). The follow-up time ranged from 3 months to 6 years. Myoclonic absence status was identified in four patients showing eyelid myoclonia with absence and one patient showing perioral myoclonia with absences. Myoclonic SE was identified in three patients showing juvenile myoclonic epilepsy. Autonomic SE was found in one patient with eyelid myoclonia with absence. SE was terminated by oral midazolam in four patients. In the other five patients, SE terminated spontaneously. Conclusions The seizure type of SE in patients with GGE is often consistent with their major symptoms. Oral midazolam may be an option to terminate SE in patients with GGE.https://doi.org/10.1186/s42494-023-00144-1Genetic generalized epilepsyStatus epilepticusElectroencephalography |
| spellingShingle | Gengyao Hu Bi Wang Beibei Chen Zezhi Wang Ze Chen Yonghong Liu Status epilepticus in patients with genetic generalized epilepsy: a case series study Acta Epileptologica Genetic generalized epilepsy Status epilepticus Electroencephalography |
| title | Status epilepticus in patients with genetic generalized epilepsy: a case series study |
| title_full | Status epilepticus in patients with genetic generalized epilepsy: a case series study |
| title_fullStr | Status epilepticus in patients with genetic generalized epilepsy: a case series study |
| title_full_unstemmed | Status epilepticus in patients with genetic generalized epilepsy: a case series study |
| title_short | Status epilepticus in patients with genetic generalized epilepsy: a case series study |
| title_sort | status epilepticus in patients with genetic generalized epilepsy a case series study |
| topic | Genetic generalized epilepsy Status epilepticus Electroencephalography |
| url | https://doi.org/10.1186/s42494-023-00144-1 |
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