Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme

Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme

Previous studies have shown that silymarin protects against various types of drug-induced liver injury, but whether the protective mechanism of silymarin against acetaminophen-induced liver injury is related to the CYP2E1 enzyme remains unclear. In this study, we investigated the effect of silymarin...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Weipei Yang, Zhongxu Liang, Chengming Wen, Xuehua Jiang, Ling Wang
Format:	Artykuł
Język:	English
Wydane:	MDPI AG 2022-12-01
Seria:	Molecules
Hasła przedmiotowe:	silymarin acetaminophen CYP2E1 acute liver injury
Dostęp online:	https://www.mdpi.com/1420-3049/27/24/8855

Podobne zapisy

Induction of Microsomal Liver Enzymes by Silymarin in Experimental Animals
od: Bahir A.R. Mshiemish, i wsp.
Wydane: (2011-07-01)

Hepato-Protective Effects of Silymarin and Coffee in Rats
od: Sidra Mumal, Akbar Waheed, Abdul Azeem, Hira Waqas Cheema, Fakhra Noureen, Abeera Zainab
Wydane: (2021-12-01)

Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity
od: Im-Sook Song, i wsp.
Wydane: (2021-04-01)

Protective effect of crude sulphated polysaccharides from Sargassum Swartzii (Turn.) C.Ag. against acetaminophen induced liver toxicity in rats
od: Khan Hira, i wsp.
Wydane: (2019-02-01)

Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats
od: Anmar M. Abdulrazzaq, i wsp.
Wydane: (2019-05-01)

Rutaecarpine Aggravates Acetaminophen-Induced Acute Liver Injury by Inducing CYP1A2
od: Meiqi Wan, i wsp.
Wydane: (2024-07-01)

The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats
od: Reza Mohebbati, i wsp.
Wydane: (2024-05-01)

Comparing Hepatoprotective Effects of Aqueous Extract of Cassia Fistula (Amaltas) Leaves and Silymarin
od: Rukhsana Munawar, Adnan Jehangir, Akbar Waheed
Wydane: (2021-11-01)

Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese Hereditary Hypertriglyceridemic Rats
od: Rostislav Vecera, i wsp.
Wydane: (2022-04-01)

Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice
od: Zhuoen He, i wsp.
Wydane: (2022-07-01)

The effects of silymarin plus glutathione on the prevention of liver ischemia-reperfusion injury
od: Dilara Aliyeva, i wsp.
Wydane: (2022-12-01)

The Effect of High-Intensity Intermittent Exercise with Silymarin Supplementation on Liver Enzymes in Male Rats of Fatty Liver Model
od: Minoo Dadban-Shahamat, i wsp.
Wydane: (2021-02-01)

A dual role of inflammation in acetaminophen-induced liver injury
od: Long Xu, i wsp.
Wydane: (2023-03-01)

Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
od: Yijun Li, i wsp.
Wydane: (2023-08-01)

Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites
od: Ying Xu, i wsp.
Wydane: (2023-12-01)

Silymarin treatment and reduction of liver enzyme levels in non-alcoholic fatty liver disease: a case report
od: Tanyaporn Chantarojanasiri
Wydane: (2023-04-01)

Hepatoprotective effects of silymarin in management of liver injury caused by tuberculosis treatment
od: Yeong Yeh Lee, i wsp.
Wydane: (2023-01-01)

Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress
od: Jabber Atashbar, i wsp.
Wydane: (2018-01-01)

Study the Effects of Oral Administration of Silymarin in Preventing Consequences of Ethanol on Liver during Pregnancy
od: HR Ahmadi-Ashtiani, i wsp.
Wydane: (2010-09-01)

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy
od: Jiaqi Zhang, i wsp.
Wydane: (2020-02-01)

Hepatoprotective Effects of Curcumin Nanomicells in Alcohol-induced Liver Injury: Comparison with Curcumin and Silymarin in Mice Model
od: Faezeh Maghsoumi, i wsp.
Wydane: (2019-12-01)

Triple Therapy with Garlic, Silymarin and Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled Clinical Trial
od: Zahra Ataee, i wsp.
Wydane: (2022-07-01)

The possibilities of silymarin extract use in alcoholic liver disease – a literature review
od: Aleksandra Kołota
Wydane: (2017-09-01)

Advances in the study of acetaminophen-induced liver injury
od: Xinghui Li, i wsp.
Wydane: (2023-08-01)

Nigella sativa's protective effect in acetaminophen induced liver toxicity in mice
od: Mohammed Abdul Muttalib Abdul Bari
Wydane: (2020-06-01)

Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury
od: Ka Wu, i wsp.
Wydane: (2017-10-01)

Nuciferine Effectively Protects Mice against Acetaminophen-Induced Liver Injury
od: Zixiong Zhou, i wsp.
Wydane: (2023-04-01)

The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease
od: Kamila Bechynska, i wsp.
Wydane: (2021-11-01)

Cathelicidin promotes liver repair after acetaminophen-induced liver injury in mice
od: Tingting Zhai, i wsp.
Wydane: (2023-04-01)

Network Pharmacology–Based Prediction and Pharmacological Validation of Effects of Astragali Radix on Acetaminophen-Induced Liver Injury
od: Yuan Peng, i wsp.
Wydane: (2022-07-01)

Using Biochemical Findings to Study the Effect of Silymarin on the Liver of Pregnant Rat that Consumed Ethanol
od: Leila Javadi, i wsp.
Wydane: (2011-07-01)

Protective effect of silymarin on tacrolimus-induced kidney and liver toxicity
od: Funda Terzi, i wsp.
Wydane: (2022-12-01)

The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury
od: Fu-Chao Liu, i wsp.
Wydane: (2021-10-01)

Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling
od: Sou Hyun Kim, i wsp.
Wydane: (2021-12-01)

Silymarin in the management of liver enzyme activity in steatohepatitis: a case report
od: Aldo Torre
Wydane: (2023-04-01)

Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice
od: Ivan Ćavar, i wsp.
Wydane: (2011-12-01)

Corrigendum: Advances in the study of acetaminophen-induced liver injury
od: Xinghui Li, i wsp.
Wydane: (2023-09-01)

Effect of Spirulina platensis on Changes in Liver Enzymes of Male BALB/c Mice Exposed to a High Dose of Acetaminophen
od: Elham Hajian Kelarijani, i wsp.
Wydane: (2023-01-01)

dose - dependent protective effects of silymarin against ccU - induced liver damage in rats
od: nada Naji AL-shAWI, i wsp.
Wydane: (2005-10-01)

Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury
od: Chenxia Hu, i wsp.
Wydane: (2020-02-01)