HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis
The design of effective gene therapy strategies for brain tumors and other neurological disorders relies on the understanding of genetic and pathophysiological alterations associated with the disease, on the biological characteristics of the target tissue, and on the development of safe vectors and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
1999-11-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558699800104 |
| _version_ | 1811299354707755008 |
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| author | Andreas Jacobs Xandra O. Breakefield Cornel Fraefel |
| author_facet | Andreas Jacobs Xandra O. Breakefield Cornel Fraefel |
| author_sort | Andreas Jacobs |
| collection | DOAJ |
| description | The design of effective gene therapy strategies for brain tumors and other neurological disorders relies on the understanding of genetic and pathophysiological alterations associated with the disease, on the biological characteristics of the target tissue, and on the development of safe vectors and expression systems to achieve efficient, targeted and regulated, therapeutic gene expression. The herpes simplex virus type 1 (HSV-1) virion is one of the most efficient of all current gene transfer vehicles with regard to nuclear gene delivery in central nervous system-derived cells including brain tumors. HSV-1-related research over the past decades has provided excellent insight into the structure and function of this virus, which, in turn, facilitated the design of innovative vector systems. Here, we review aspects of HSV-1 structure, replication and pathogenesis, which are relevant for the engineering of HSV-1-based vectors. |
| first_indexed | 2024-04-13T06:34:52Z |
| format | Article |
| id | doaj.art-a33a4ed76a73400f8d2eaa0dabdc2251 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 1522-8002 |
| language | English |
| last_indexed | 2024-04-13T06:34:52Z |
| publishDate | 1999-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-a33a4ed76a73400f8d2eaa0dabdc22512022-12-22T02:57:58ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80021999-11-011538740110.1038/sj.neo.7900055HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and PathogenesisAndreas Jacobs0Xandra O. Breakefield1Cornel Fraefel2Department^of Neurology at the University and MPI for Neurological Research, Cologne, GermanyDepartment^of Neurology at the University and MPI for Neurological Research, Cologne, GermanyNeurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, BostonThe design of effective gene therapy strategies for brain tumors and other neurological disorders relies on the understanding of genetic and pathophysiological alterations associated with the disease, on the biological characteristics of the target tissue, and on the development of safe vectors and expression systems to achieve efficient, targeted and regulated, therapeutic gene expression. The herpes simplex virus type 1 (HSV-1) virion is one of the most efficient of all current gene transfer vehicles with regard to nuclear gene delivery in central nervous system-derived cells including brain tumors. HSV-1-related research over the past decades has provided excellent insight into the structure and function of this virus, which, in turn, facilitated the design of innovative vector systems. Here, we review aspects of HSV-1 structure, replication and pathogenesis, which are relevant for the engineering of HSV-1-based vectors.http://www.sciencedirect.com/science/article/pii/S1476558699800104herpes simplex virusgene therapyrecombinant HSV-1amplicon |
| spellingShingle | Andreas Jacobs Xandra O. Breakefield Cornel Fraefel HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis Neoplasia: An International Journal for Oncology Research herpes simplex virus gene therapy recombinant HSV-1 amplicon |
| title | HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis |
| title_full | HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis |
| title_fullStr | HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis |
| title_full_unstemmed | HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis |
| title_short | HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis |
| title_sort | hsv 1 based vectors for gene therapy of neurological diseases and brain tumors part i hsv 1 structure replication and pathogenesis |
| topic | herpes simplex virus gene therapy recombinant HSV-1 amplicon |
| url | http://www.sciencedirect.com/science/article/pii/S1476558699800104 |
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