Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis
All corneal cross-linking techniques attenuated disease progression in patients with pediatric keratoconus for at least one year based on a meta-analysis. A standard and accelerated technique led to marked improvement in visual acuity. We determined the efficacy and safety of corneal cross-linking (...
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2021-06-01
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author | Hidenaga Kobashi Osamu Hieda Motohiro Itoi Kazutaka Kamiya Naoko Kato Jun Shimazaki Kazuo Tsubota the Keratoconus Study Group of Japan |
author_facet | Hidenaga Kobashi Osamu Hieda Motohiro Itoi Kazutaka Kamiya Naoko Kato Jun Shimazaki Kazuo Tsubota the Keratoconus Study Group of Japan |
author_sort | Hidenaga Kobashi |
collection | DOAJ |
description | All corneal cross-linking techniques attenuated disease progression in patients with pediatric keratoconus for at least one year based on a meta-analysis. A standard and accelerated technique led to marked improvement in visual acuity. We determined the efficacy and safety of corneal cross-linking (CXL) in pediatric keratoconus by conducting a systematic review and meta-analysis. The PubMed and Cochrane databases were searched for relevant studies on the effects of standard, transepithelial, and/or accelerated CXL protocols in patients aged 18 years or younger. Standardized mean differences with 95% confidence intervals were calculated to compare the data collected at baseline and 12 months. The primary outcomes were maximum keratometry (Kmax) and uncorrected visual acuity (UCVA), and the secondary outcomes were the thinnest corneal thickness (TCT), best-corrected visual acuity (BCVA), and manifest refraction spherical equivalent or cylindrical refraction. Our search yielded 7913 publications, of which 26 were included in our systematic review and 21 were included in the meta-analysis. Standard CXL significantly improved the Kmax, UCVA, and BCVA, and significantly decreased the TCT. Accelerated CXL significantly improved UCVA and BCVA. In the transepithelial and accelerated-transepithelial CXL methods, each measurable parameter did not change after treatments. All CXL techniques attenuated disease progression in patients with pediatric keratoconus for at least one year. Standard and accelerated CXL led to marked improvement in visual acuity. |
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id | doaj.art-a33a56db37e84c9ca0b6746b75c1e012 |
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issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T10:24:39Z |
publishDate | 2021-06-01 |
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series | Journal of Clinical Medicine |
spelling | doaj.art-a33a56db37e84c9ca0b6746b75c1e0122023-11-22T00:07:47ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011012262610.3390/jcm10122626Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-AnalysisHidenaga Kobashi0Osamu Hieda1Motohiro Itoi2Kazutaka Kamiya3Naoko Kato4Jun Shimazaki5Kazuo Tsubota6the Keratoconus Study Group of JapanDepartment of Ophthalmology, School of Medicine, Keio University, Tokyo 160-8582, JapanDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Ophthalmology, School of Medicine, University of Kitasato, Kanagawa 252-0329, JapanDepartment of Ophthalmology, School of Medicine, Keio University, Tokyo 160-8582, JapanDepartment of Ophthalmology, Ichikawa General Hospital, Tokyo Dental College, Chiba 272-8513, JapanDepartment of Ophthalmology, School of Medicine, Keio University, Tokyo 160-8582, JapanAll corneal cross-linking techniques attenuated disease progression in patients with pediatric keratoconus for at least one year based on a meta-analysis. A standard and accelerated technique led to marked improvement in visual acuity. We determined the efficacy and safety of corneal cross-linking (CXL) in pediatric keratoconus by conducting a systematic review and meta-analysis. The PubMed and Cochrane databases were searched for relevant studies on the effects of standard, transepithelial, and/or accelerated CXL protocols in patients aged 18 years or younger. Standardized mean differences with 95% confidence intervals were calculated to compare the data collected at baseline and 12 months. The primary outcomes were maximum keratometry (Kmax) and uncorrected visual acuity (UCVA), and the secondary outcomes were the thinnest corneal thickness (TCT), best-corrected visual acuity (BCVA), and manifest refraction spherical equivalent or cylindrical refraction. Our search yielded 7913 publications, of which 26 were included in our systematic review and 21 were included in the meta-analysis. Standard CXL significantly improved the Kmax, UCVA, and BCVA, and significantly decreased the TCT. Accelerated CXL significantly improved UCVA and BCVA. In the transepithelial and accelerated-transepithelial CXL methods, each measurable parameter did not change after treatments. All CXL techniques attenuated disease progression in patients with pediatric keratoconus for at least one year. Standard and accelerated CXL led to marked improvement in visual acuity.https://www.mdpi.com/2077-0383/10/12/2626keratoconuscorneal cross-linkingpediatric |
spellingShingle | Hidenaga Kobashi Osamu Hieda Motohiro Itoi Kazutaka Kamiya Naoko Kato Jun Shimazaki Kazuo Tsubota the Keratoconus Study Group of Japan Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis Journal of Clinical Medicine keratoconus corneal cross-linking pediatric |
title | Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis |
title_full | Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis |
title_fullStr | Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis |
title_short | Corneal Cross-Linking for Paediatric Keratoconus: A Systematic Review and Meta-Analysis |
title_sort | corneal cross linking for paediatric keratoconus a systematic review and meta analysis |
topic | keratoconus corneal cross-linking pediatric |
url | https://www.mdpi.com/2077-0383/10/12/2626 |
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