Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis
Implant loosening remains a major clinical challenge for osteoporotic patients. This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis, which results in poor bone repair. Strontium (Sr) has been widely accepted as an anti-osteopo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-04-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20302449 |
| _version_ | 1827279198953144320 |
|---|---|
| author | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu |
| author_facet | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu |
| author_sort | Zhen Geng |
| collection | DOAJ |
| description | Implant loosening remains a major clinical challenge for osteoporotic patients. This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis, which results in poor bone repair. Strontium (Sr) has been widely accepted as an anti-osteoporosis element. In this study, we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions. The results showed that Ca and Sr exhibited different mineralization behaviors. The main mineralization products for Ca were CaHPO4·2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased. The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased. The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion, spreading, proliferation, and osteogenic differentiation. In addition, Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion. Moreover, the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity, improve new bone formation, and enhance bone-implant integration. This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients. |
| first_indexed | 2024-04-24T08:15:13Z |
| format | Article |
| id | doaj.art-a33a9676e57442b6a67ce69166cdf679 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:15:13Z |
| publishDate | 2021-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-a33a9676e57442b6a67ce69166cdf6792024-04-17T04:14:10ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-04-0164905915Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesisZhen Geng0Luli Ji1Zhaoyang Li2Jing Wang3Hongyan He4Zhenduo Cui5Xianjin Yang6Changsheng Liu7Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai, 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai, 200237, ChinaTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, China; Corresponding author. School of Materials Science and Engineering, Tianjin University, Yaguan Road, Tianjin, 300350, China.Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Corresponding author. Key Laboratory for Ultrafine Materials of Ministry of Education & the State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Meilong Road, Shanghai, 200237, China. (J. Wang).Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai, 200237, ChinaTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, ChinaTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, ChinaImplant loosening remains a major clinical challenge for osteoporotic patients. This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis, which results in poor bone repair. Strontium (Sr) has been widely accepted as an anti-osteoporosis element. In this study, we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions. The results showed that Ca and Sr exhibited different mineralization behaviors. The main mineralization products for Ca were CaHPO4·2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased. The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased. The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion, spreading, proliferation, and osteogenic differentiation. In addition, Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion. Moreover, the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity, improve new bone formation, and enhance bone-implant integration. This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients.http://www.sciencedirect.com/science/article/pii/S2452199X20302449CalciumStrontiumMineralizationOsteoclast activityOsseointegration |
| spellingShingle | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis Bioactive Materials Calcium Strontium Mineralization Osteoclast activity Osseointegration |
| title | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| title_full | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| title_fullStr | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| title_full_unstemmed | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| title_short | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| title_sort | nano needle strontium substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis |
| topic | Calcium Strontium Mineralization Osteoclast activity Osseointegration |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20302449 |
| work_keys_str_mv | AT zhengeng nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT luliji nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT zhaoyangli nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT jingwang nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT hongyanhe nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT zhenduocui nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT xianjinyang nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis AT changshengliu nanoneedlestrontiumsubstitutedapatitecoatingenhancesosteoporoticosseointegrationthroughpromotingosteogenesisandinhibitingosteoclastogenesis |