The Role of Harmine in Up-regulating p53 Gene Expression and Inducing Apoptosis in MCF-7 Cell Line

The Role of Harmine in Up-regulating p53 Gene Expression and Inducing Apoptosis in MCF-7 Cell Line

Background: As a major tumor suppressor gene, P53 plays a principal role in the apoptosis of cancer cells. Harmine is a harmal-derived alkaloid with antioxidant and anticancer properties. This study was designed to assess the ability of harmine to express P53 gene and stimulate apoptosis in breast c...

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Bibliographic Details
Main Authors: Shiva Roshankhah, Babak Arji Rodsari, Cyrus Jalili, Mohammad Reza Salahshoor
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2020-01-01
Series:Middle East Journal of Cancer
Subjects:
harmine
p53 gene
mcf-7
apoptosis
cell line
Online Access:http://mejc.sums.ac.ir/article_45950.html

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