Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.
<h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166661/pdf/?tool=EBI |
| _version_ | 1818742596576477184 |
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| author | Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom |
| author_facet | Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom |
| author_sort | Claes Ohlsson |
| collection | DOAJ |
| description | <h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</h4>This is a retrospective cohort study. Detailed growth charts were retrieved for the men participating in the population-based GOOD (Gothenburg Osteoporosis and Obesity Determinants) study (n=573). Body composition was analysed using dual X-ray absorptiometry and computed tomography at 18-20 years of age. Age and BMI at AR were calculated using pediatric growth charts and AR was defined as the lowest BMI between 3 and 9 years of age.<h4>Results</h4>Subjects were divided into early (age at AR below 5.4 years of age), middle (age at AR 5.4 to 6.8 years of age) and late (age at AR after 6.8 years of age) age at AR tertiles. Subjects in the early age at AR tertile had higher young adult BMI (+8%), whole body fat mass (+34%) and amount of subcutaneous adipose tissue (+61%) than the subjects in the middle and late tertiles (p<0.01). The early age at AR tertile had an increased risk of obesity (Odds Ratio 4.1 [95% CI 1.2-13.9]) compared with the middle and late tertiles. In addition, the early age at AR tertile had Peak Height Velocity (PHV) 7 months earlier than the late tertile.<h4>Conclusions</h4>Early age at AR was associated with young adult obesity as a consequence of a high amount of subcutaneous adipose tissue in men. In addition we made the novel observation that early age at AR was associated with an early puberty in men. |
| first_indexed | 2024-12-18T02:15:02Z |
| format | Article |
| id | doaj.art-a33ca602e49e47c1a63fccb902375362 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T02:15:02Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a33ca602e49e47c1a63fccb9023753622022-12-21T21:24:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4940410.1371/journal.pone.0049404Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study.Claes OhlssonMattias LorentzonEnsio NorjavaaraJenny M Kindblom<h4>Objective</h4>Age at adiposity rebound (AR) is associated with obesity and Type 2 Diabetes in adults. The aim of the present study was to investigate the role of age at AR in adult fat mass, fat distribution and pubertal timing for a Swedish cohort.<h4>Patients and methods</h4>This is a retrospective cohort study. Detailed growth charts were retrieved for the men participating in the population-based GOOD (Gothenburg Osteoporosis and Obesity Determinants) study (n=573). Body composition was analysed using dual X-ray absorptiometry and computed tomography at 18-20 years of age. Age and BMI at AR were calculated using pediatric growth charts and AR was defined as the lowest BMI between 3 and 9 years of age.<h4>Results</h4>Subjects were divided into early (age at AR below 5.4 years of age), middle (age at AR 5.4 to 6.8 years of age) and late (age at AR after 6.8 years of age) age at AR tertiles. Subjects in the early age at AR tertile had higher young adult BMI (+8%), whole body fat mass (+34%) and amount of subcutaneous adipose tissue (+61%) than the subjects in the middle and late tertiles (p<0.01). The early age at AR tertile had an increased risk of obesity (Odds Ratio 4.1 [95% CI 1.2-13.9]) compared with the middle and late tertiles. In addition, the early age at AR tertile had Peak Height Velocity (PHV) 7 months earlier than the late tertile.<h4>Conclusions</h4>Early age at AR was associated with young adult obesity as a consequence of a high amount of subcutaneous adipose tissue in men. In addition we made the novel observation that early age at AR was associated with an early puberty in men.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166661/pdf/?tool=EBI |
| spellingShingle | Claes Ohlsson Mattias Lorentzon Ensio Norjavaara Jenny M Kindblom Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. PLoS ONE |
| title | Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. |
| title_full | Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. |
| title_fullStr | Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. |
| title_full_unstemmed | Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. |
| title_short | Age at adiposity rebound is associated with fat mass in young adult males-the GOOD study. |
| title_sort | age at adiposity rebound is associated with fat mass in young adult males the good study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166661/pdf/?tool=EBI |
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