Catalysis of protein folding by chaperones accelerates evolutionary dynamics in adapting cell populations.
Although molecular chaperones are essential components of protein homeostatic machinery, their mechanism of action and impact on adaptation and evolutionary dynamics remain controversial. Here we developed a physics-based ab initio multi-scale model of a living cell for population dynamics simulatio...
Main Authors: | Murat Cetinbaş, Eugene I Shakhnovich |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC3820506?pdf=render |
Similar Items
-
Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding
by: Soichiro Kawagoe, et al.
Published: (2022-02-01) -
Non-Equilibrium Protein Folding and Activation by ATP-Driven Chaperones
by: Huafeng Xu
Published: (2022-06-01) -
Evolutionary selection of proteins with two folds
by: Joseph W. Schafer, et al.
Published: (2023-09-01) -
Protein Folding Sculpting Evolutionary Change
by: Lindquist, Susan
Published: (2011) -
Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding /
by: Fersht, Alan, 1943-
Published: (1999)