Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis

Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis

Abstract Background Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are active players in melanoma progression involved in the formation of the...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D’Oronzo, Francesco Silvestris
Format: Artykuł
Język:English
Wydane: BMC 2019-07-01
Seria:Journal of Translational Medicine
Hasła przedmiotowe:
Melanoma
Exosomes
Bone metastasis
CXCR7
CXCR4
Dostęp online:http://link.springer.com/article/10.1186/s12967-019-1982-4

Internet

http://link.springer.com/article/10.1186/s12967-019-1982-4

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