Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress indepe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13281 |
| _version_ | 1818843893180923904 |
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| author | L. Fusi E. Brunello Z. Yan M. Irving |
| author_facet | L. Fusi E. Brunello Z. Yan M. Irving |
| author_sort | L. Fusi |
| collection | DOAJ |
| description | Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium. |
| first_indexed | 2024-12-19T05:05:06Z |
| format | Article |
| id | doaj.art-a33d9371f6e84246a2c0cb6421e371e0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:05:06Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a33d9371f6e84246a2c0cb6421e371e02022-12-21T20:34:58ZengNature PortfolioNature Communications2041-17232016-10-01711910.1038/ncomms13281Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscleL. Fusi0E. Brunello1Z. Yan2M. Irving3Randall Division of Cell and Molecular Biophysics and BHF Centre of Research Excellence, King’s College LondonRandall Division of Cell and Molecular Biophysics and BHF Centre of Research Excellence, King’s College LondonRandall Division of Cell and Molecular Biophysics and BHF Centre of Research Excellence, King’s College LondonRandall Division of Cell and Molecular Biophysics and BHF Centre of Research Excellence, King’s College LondonRecent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium.https://doi.org/10.1038/ncomms13281 |
| spellingShingle | L. Fusi E. Brunello Z. Yan M. Irving Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle Nature Communications |
| title | Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle |
| title_full | Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle |
| title_fullStr | Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle |
| title_full_unstemmed | Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle |
| title_short | Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle |
| title_sort | thick filament mechano sensing is a calcium independent regulatory mechanism in skeletal muscle |
| url | https://doi.org/10.1038/ncomms13281 |
| work_keys_str_mv | AT lfusi thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT ebrunello thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT zyan thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle AT mirving thickfilamentmechanosensingisacalciumindependentregulatorymechanisminskeletalmuscle |