Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases. However, whether there is a substrate preference for PS/γ-secretase proc...

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Bibliographic Details
Main Authors: Mei C. Q. Houser, Yuliia Turchyna, Florian Perrin, Lori Chibnik, Oksana Berezovska, Masato Maesako
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biosensors
Subjects:
PS/γ-secretase
FRET
multiplexing
APP C99
Notch1 N100
Online Access:https://www.mdpi.com/2079-6374/11/6/169

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