Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia)
Background: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later lif...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2016-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2016/1452-82581603293D.pdf |
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| author | Dželajlija Darko D. Spasić Slavica S. Kotur-Stevuljević Jelena M. Bogavac-Stanojević Nataša B. |
| author_facet | Dželajlija Darko D. Spasić Slavica S. Kotur-Stevuljević Jelena M. Bogavac-Stanojević Nataša B. |
| author_sort | Dželajlija Darko D. |
| collection | DOAJ |
| description | Background: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later life, interaction with a sedentary way of life, as well as unhealthy nutrition, smoking, alcohol consumption, obesity and family history of cardiovascular disease cause the burden of atherosclerotic disease. Methods: Study included 624 children (316 boys, 308 girls), aged from 7-13 years. We analysed socio-demographic data (BMI, blood pressure, cardiovascular family history, smoking status), as well as lipid status with lipoprotein little a-Lp(a), and apolipoproteins: Apo AI, Apo B-100 for all children. This enabled us to calculate new atherogenic indices Tg/HDL-c, lipid tetrad index (LTI) and lipid pentad index (LPI). Cardiovascular risk for later life was estimated by using modified Risk Score for Young Individuals (RS), which divided the subjects according to the score level: low, medium and higher risk. Results: The older children (13 y) had better lipid status than the younger children, i.e. significantly lower total cholesterol, LDL-C, triglycerides and non-HDL-C concentration and significantly higher HDL-C concentration than the younger children and this was in accordance with the RS level. Children with a positive family history of CV disease had significantly higher Lp(a) concentration and blood pressure. LPI was significantly higher in children with a higher RS. Conclusions: The results of our work could be used for cardiovascular risk assessment in apparently healthy children to provide preventive measures which could control the changeable risk factors. |
| first_indexed | 2024-12-12T18:18:49Z |
| format | Article |
| id | doaj.art-a33f2d67f48a4f328238156be2421ac5 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-12T18:18:49Z |
| publishDate | 2016-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-a33f2d67f48a4f328238156be2421ac52022-12-22T00:16:13ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662016-01-013532933011452-82581603293DCardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia)Dželajlija Darko D.0Spasić Slavica S.1Kotur-Stevuljević Jelena M.2https://orcid.org/0000-0002-6980-3069Bogavac-Stanojević Nataša B.3https://orcid.org/0000-0001-7004-4701College of Technical Sciences, PančevoUniversity of Belgrade, Faculty of Pharmacy, Department of Medical BiochemistryUniversity of Belgrade, Faculty of Pharmacy, Department of Medical BiochemistryUniversity of Belgrade, Faculty of Pharmacy, Department of Medical BiochemistryBackground: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later life, interaction with a sedentary way of life, as well as unhealthy nutrition, smoking, alcohol consumption, obesity and family history of cardiovascular disease cause the burden of atherosclerotic disease. Methods: Study included 624 children (316 boys, 308 girls), aged from 7-13 years. We analysed socio-demographic data (BMI, blood pressure, cardiovascular family history, smoking status), as well as lipid status with lipoprotein little a-Lp(a), and apolipoproteins: Apo AI, Apo B-100 for all children. This enabled us to calculate new atherogenic indices Tg/HDL-c, lipid tetrad index (LTI) and lipid pentad index (LPI). Cardiovascular risk for later life was estimated by using modified Risk Score for Young Individuals (RS), which divided the subjects according to the score level: low, medium and higher risk. Results: The older children (13 y) had better lipid status than the younger children, i.e. significantly lower total cholesterol, LDL-C, triglycerides and non-HDL-C concentration and significantly higher HDL-C concentration than the younger children and this was in accordance with the RS level. Children with a positive family history of CV disease had significantly higher Lp(a) concentration and blood pressure. LPI was significantly higher in children with a higher RS. Conclusions: The results of our work could be used for cardiovascular risk assessment in apparently healthy children to provide preventive measures which could control the changeable risk factors.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2016/1452-82581603293D.pdfchildrenobesitylipidsfamily history of cvdrisk score |
| spellingShingle | Dželajlija Darko D. Spasić Slavica S. Kotur-Stevuljević Jelena M. Bogavac-Stanojević Nataša B. Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) Journal of Medical Biochemistry children obesity lipids family history of cvd risk score |
| title | Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) |
| title_full | Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) |
| title_fullStr | Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) |
| title_full_unstemmed | Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) |
| title_short | Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) |
| title_sort | cardiovascular risk factors in 7 13 years old children from vojvodina serbia |
| topic | children obesity lipids family history of cvd risk score |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2016/1452-82581603293D.pdf |
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