Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study
Isotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study div...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/11/1286 |
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| author | Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte |
| author_facet | Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte |
| author_sort | Reham AlJasser |
| collection | DOAJ |
| description | Isotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study divided 180 subjects into six groups according to periodontal health status and INN usage as follows: healthy periodontium receiving INN (HINN; <i>n</i> = 30); those with generalized plaque-induced gingivitis receiving INN (GINN; <i>n</i> = 30); and those with stage I generalized periodontitis receiving INN (PINN; <i>n</i> = 30). Subjects not taking INN, were categorized in the same manner: those with a healthy periodontium (HC; <i>n</i> = 30); those with generalized plaque-induced gingivitis (GC; <i>n</i> = 30); and those with generalized periodontitis stage I (PC; <i>n</i> = 30). Plaque samples were collected to determine the prevalence of four periodontal pathogens (<i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, and <i>Fusobacterium nucleatum)</i> in each study group using real-time polymerase chain reaction. Data were analyzed using IBM SPSS software, and multiple regression analysis was performed for each parameter tested in each group at a significance level of 0.05. All INN groups showed significantly lower levels of <i>P. gingivalis</i>, <i>T. forsythia</i>, and <i>T. denticola</i> and higher levels of <i>F. nucleatum</i> (<i>p <</i> 0.001). INN had an observable antimicrobial effect on the periodontal pathogen count in patients with plaque-induced gingivitis and chronic periodontitis. INN may have a potential additive antimicrobial value in the treatment of periodontal disease. |
| first_indexed | 2024-03-10T05:46:20Z |
| format | Article |
| id | doaj.art-a341a3b5b6974b9cb849c345c3ec94ee |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T05:46:20Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a341a3b5b6974b9cb849c345c3ec94ee2023-11-22T22:09:20ZengMDPI AGAntibiotics2079-63822021-10-011011128610.3390/antibiotics10111286Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control StudyReham AlJasser0Razan AlAqeely1Afnan AlZahrani2Manal AlKenani3Sadeem AlQahtani4Mohammed AlSarhan5Dalal AlOtaibi6Rhodanne Lambarte7Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaMinistry of Health, Riyadh 11176, Saudi ArabiaSaudi Board of Periodontics, Riyadh 11545, Saudi ArabiaSaudi Board of Periodontics, Riyadh 11545, Saudi ArabiaDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaMolecular and Cell Biology Laboratory, Prince Naif Bin AbdulAziz Health Research Center, College of Dentistry, King Saud University, Riyadh 11545, Saudi ArabiaIsotretinoin (INN), a drug used to treat severe acne, has anti-inflammatory and antibacterial properties. INN may affect periodontal pathogenic bacteria, so we aimed to study the effect of INN on intraoral microbial profiles of periodontal disease and healthy periodontium. Our case-control study divided 180 subjects into six groups according to periodontal health status and INN usage as follows: healthy periodontium receiving INN (HINN; <i>n</i> = 30); those with generalized plaque-induced gingivitis receiving INN (GINN; <i>n</i> = 30); and those with stage I generalized periodontitis receiving INN (PINN; <i>n</i> = 30). Subjects not taking INN, were categorized in the same manner: those with a healthy periodontium (HC; <i>n</i> = 30); those with generalized plaque-induced gingivitis (GC; <i>n</i> = 30); and those with generalized periodontitis stage I (PC; <i>n</i> = 30). Plaque samples were collected to determine the prevalence of four periodontal pathogens (<i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, and <i>Fusobacterium nucleatum)</i> in each study group using real-time polymerase chain reaction. Data were analyzed using IBM SPSS software, and multiple regression analysis was performed for each parameter tested in each group at a significance level of 0.05. All INN groups showed significantly lower levels of <i>P. gingivalis</i>, <i>T. forsythia</i>, and <i>T. denticola</i> and higher levels of <i>F. nucleatum</i> (<i>p <</i> 0.001). INN had an observable antimicrobial effect on the periodontal pathogen count in patients with plaque-induced gingivitis and chronic periodontitis. INN may have a potential additive antimicrobial value in the treatment of periodontal disease.https://www.mdpi.com/2079-6382/10/11/1286oral microbesperiodontal pathogensisotretinoinperiodontal therapy |
| spellingShingle | Reham AlJasser Razan AlAqeely Afnan AlZahrani Manal AlKenani Sadeem AlQahtani Mohammed AlSarhan Dalal AlOtaibi Rhodanne Lambarte Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study Antibiotics oral microbes periodontal pathogens isotretinoin periodontal therapy |
| title | Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study |
| title_full | Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study |
| title_fullStr | Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study |
| title_full_unstemmed | Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study |
| title_short | Antimicrobial Effect of Isotretinoin Therapy on Periodontal Pathogens: A Case-Control Study |
| title_sort | antimicrobial effect of isotretinoin therapy on periodontal pathogens a case control study |
| topic | oral microbes periodontal pathogens isotretinoin periodontal therapy |
| url | https://www.mdpi.com/2079-6382/10/11/1286 |
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