Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

The overproduction of adrenocorticotropic hormone (ACTH), in conditions such as Cushing’s disease and congenital adrenal hyperplasia (CAH), leads to significant morbidity. Current treatment with glucocorticoids does not adequately suppress plasma ACTH, resulting in excess adrenal androgen production...

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Bibliographic Details
Main Authors: Rachel Forfar, Mashal Hussain, Puneet Khurana, Jennifer Cook, Steve Lewis, Dillon Popat, David Jackson, Ed McIver, Jeff Jerman, Debra Taylor, Adrian JL Clark, Li F Chan
Format: Article
Language:English
Published: Bioscientifica 2022-11-01
Series:Endocrine Connections
Subjects:
mrap
mc2r
adrenal
gpcr antagonism
drug discovery
Online Access:https://ec.bioscientifica.com/view/journals/ec/11/12/EC-22-0338.xml

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