Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory
Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00058/full |
| _version_ | 1828278790333136896 |
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| author | Madalena Esteves Madalena Esteves Madalena Esteves Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Paulo Marques Paulo Marques Paulo Marques Teresa C. Castanho Teresa C. Castanho Teresa C. Castanho Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes José M. Soares José M. Soares José M. Soares Armando Almeida Armando Almeida Armando Almeida Nadine C. Santos Nadine C. Santos Nadine C. Santos Nuno Sousa Nuno Sousa Nuno Sousa Hugo Leite-Almeida Hugo Leite-Almeida Hugo Leite-Almeida |
| author_facet | Madalena Esteves Madalena Esteves Madalena Esteves Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Paulo Marques Paulo Marques Paulo Marques Teresa C. Castanho Teresa C. Castanho Teresa C. Castanho Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes José M. Soares José M. Soares José M. Soares Armando Almeida Armando Almeida Armando Almeida Nadine C. Santos Nadine C. Santos Nadine C. Santos Nuno Sousa Nuno Sousa Nuno Sousa Hugo Leite-Almeida Hugo Leite-Almeida Hugo Leite-Almeida |
| author_sort | Madalena Esteves |
| collection | DOAJ |
| description | Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function have never been established. Herein, we assessed functional laterality during a working memory task (N-Back) in a healthy aging cohort (over 50 years old) and associated these asymmetries with performance in the test. Activity of lobule VI of the cerebellar hemisphere and angular gyrus was found to be lateralized to the right hemisphere, while the precentral gyrus presented left > right activation during this task. Interestingly, 1-Back accuracy was positively correlated with left > right superior parietal lobule activation, which was mostly due to the influence of the left hemisphere. In conclusion, although regions were mostly symmetrically activated during the N-Back task, performance in working memory in aged individuals seems to benefit from lateralized involvement of the superior parietal lobule. |
| first_indexed | 2024-04-13T07:35:03Z |
| format | Article |
| id | doaj.art-a343c8f22fcc4ecaa945b20b306e15f1 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T07:35:03Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a343c8f22fcc4ecaa945b20b306e15f12022-12-22T02:56:12ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-03-011010.3389/fnagi.2018.00058348376Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working MemoryMadalena Esteves0Madalena Esteves1Madalena Esteves2Ricardo Magalhães3Ricardo Magalhães4Ricardo Magalhães5Paulo Marques6Paulo Marques7Paulo Marques8Teresa C. Castanho9Teresa C. Castanho10Teresa C. Castanho11Carlos Portugal-Nunes12Carlos Portugal-Nunes13Carlos Portugal-Nunes14José M. Soares15José M. Soares16José M. Soares17Armando Almeida18Armando Almeida19Armando Almeida20Nadine C. Santos21Nadine C. Santos22Nadine C. Santos23Nuno Sousa24Nuno Sousa25Nuno Sousa26Hugo Leite-Almeida27Hugo Leite-Almeida28Hugo Leite-Almeida29Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga, PortugalClinical Academic Center — Braga, Braga, PortugalFunctional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function have never been established. Herein, we assessed functional laterality during a working memory task (N-Back) in a healthy aging cohort (over 50 years old) and associated these asymmetries with performance in the test. Activity of lobule VI of the cerebellar hemisphere and angular gyrus was found to be lateralized to the right hemisphere, while the precentral gyrus presented left > right activation during this task. Interestingly, 1-Back accuracy was positively correlated with left > right superior parietal lobule activation, which was mostly due to the influence of the left hemisphere. In conclusion, although regions were mostly symmetrically activated during the N-Back task, performance in working memory in aged individuals seems to benefit from lateralized involvement of the superior parietal lobule.http://journal.frontiersin.org/article/10.3389/fnagi.2018.00058/fulllateralityN-backagingfMRIsuperior parietal |
| spellingShingle | Madalena Esteves Madalena Esteves Madalena Esteves Ricardo Magalhães Ricardo Magalhães Ricardo Magalhães Paulo Marques Paulo Marques Paulo Marques Teresa C. Castanho Teresa C. Castanho Teresa C. Castanho Carlos Portugal-Nunes Carlos Portugal-Nunes Carlos Portugal-Nunes José M. Soares José M. Soares José M. Soares Armando Almeida Armando Almeida Armando Almeida Nadine C. Santos Nadine C. Santos Nadine C. Santos Nuno Sousa Nuno Sousa Nuno Sousa Hugo Leite-Almeida Hugo Leite-Almeida Hugo Leite-Almeida Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory Frontiers in Aging Neuroscience laterality N-back aging fMRI superior parietal |
| title | Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory |
| title_full | Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory |
| title_fullStr | Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory |
| title_full_unstemmed | Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory |
| title_short | Functional Hemispheric (A)symmetries in the Aged Brain—Relevance for Working Memory |
| title_sort | functional hemispheric a symmetries in the aged brain relevance for working memory |
| topic | laterality N-back aging fMRI superior parietal |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2018.00058/full |
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