Activated fibroblasts modify keratinocyte stem niche through TET1 and IL-6 to promote their rapid transformation in a mouse model of prenatal arsenic exposure

Activated fibroblasts modify keratinocyte stem niche through TET1 and IL-6 to promote their rapid transformation in a mouse model of prenatal arsenic exposure

Abstract Early life exposure to environmental pollutants such as arsenic (As) can increase the risk of cancers in the offspring. In an earlier study, we showed that only prenatal As exposure significantly increases epidermal stem cell proliferation and accelerates skin tumorigenesis in BALB/c mouse...

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Bibliographic Details
Main Authors: Anchal Chauhan, Siddhartha Gangopadhyay, Kavita Koshta, Sukhveer Singh, Dhirendra Singh, Vikas Srivastava
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Inorganic as
Prenatal exposure
Fibroblast activation
IL-6
EMT
Stem cell niche
Online Access:https://doi.org/10.1038/s41598-024-56547-8

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