Potential therapeutic effects of baicalin and baicalein
Objective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.Mat...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024-01-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_22307_fbbf8c634d8a87b6370c205f61d51b11.pdf |
| _version_ | 1827586085246468096 |
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| author | Kamyar Sabry Zahra Jamshidi Seyed Ahmad Emami Amir Hossein Sahebkar Maryam Akaberi |
| author_facet | Kamyar Sabry Zahra Jamshidi Seyed Ahmad Emami Amir Hossein Sahebkar Maryam Akaberi |
| author_sort | Kamyar Sabry |
| collection | DOAJ |
| description | Objective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.Materials and Methods: An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.Results: According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.Conclusion: The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different in vitro and in vivo models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested. |
| first_indexed | 2024-03-08T23:56:59Z |
| format | Article |
| id | doaj.art-a344402c237045e49d6c48f4c76f82ec |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-03-08T23:56:59Z |
| publishDate | 2024-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-a344402c237045e49d6c48f4c76f82ec2023-12-13T04:13:36ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492024-01-01141234910.22038/ajp.2023.2230722307Potential therapeutic effects of baicalin and baicaleinKamyar Sabry0Zahra Jamshidi1Seyed Ahmad Emami2Amir Hossein Sahebkar3Maryam Akaberi4Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.Materials and Methods: An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.Results: According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.Conclusion: The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different in vitro and in vivo models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.https://ajp.mums.ac.ir/article_22307_fbbf8c634d8a87b6370c205f61d51b11.pdfbaicalinbaicaleinhepatoprotectivecancermetabolic syndromeocular problems |
| spellingShingle | Kamyar Sabry Zahra Jamshidi Seyed Ahmad Emami Amir Hossein Sahebkar Maryam Akaberi Potential therapeutic effects of baicalin and baicalein Avicenna Journal of Phytomedicine baicalin baicalein hepatoprotective cancer metabolic syndrome ocular problems |
| title | Potential therapeutic effects of baicalin and baicalein |
| title_full | Potential therapeutic effects of baicalin and baicalein |
| title_fullStr | Potential therapeutic effects of baicalin and baicalein |
| title_full_unstemmed | Potential therapeutic effects of baicalin and baicalein |
| title_short | Potential therapeutic effects of baicalin and baicalein |
| title_sort | potential therapeutic effects of baicalin and baicalein |
| topic | baicalin baicalein hepatoprotective cancer metabolic syndrome ocular problems |
| url | https://ajp.mums.ac.ir/article_22307_fbbf8c634d8a87b6370c205f61d51b11.pdf |
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