Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials
Abstract Objective This study aimed to investigate the possible effect of omega-3 fatty acids on reducing the mortality of sepsis and sepsis-induced acute respiratory distress syndrome (ARDS) in adults. Methods Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) databas...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Nutrition Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12937-018-0356-8 |
| _version_ | 1819163045287428096 |
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| author | HuaiSheng Chen Su Wang Ying Zhao YuTian Luo HuaSheng Tong Lei Su |
| author_facet | HuaiSheng Chen Su Wang Ying Zhao YuTian Luo HuaSheng Tong Lei Su |
| author_sort | HuaiSheng Chen |
| collection | DOAJ |
| description | Abstract Objective This study aimed to investigate the possible effect of omega-3 fatty acids on reducing the mortality of sepsis and sepsis-induced acute respiratory distress syndrome (ARDS) in adults. Methods Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) database, WangFang database, and Chinese BioMedical Literature Database from their inception to March 6, 2017, were searched using systematic review researching methods. Five factors were analyzed to investigate the correlation between omega-3 fatty acids (either parenteral or enteral supplementation) and mortality rate. Results Forty randomized controlled trials (RCTs) were initially included, but only 25 of them assessed mortality. Of these RCTs, nine used enteral nutrition (EN) and 16 used parenteral nutrition (PN). The total mortality rate in the omega-3 fatty acid group was lower than that in the control group. However, the odds ratio (OR) value was not significantly different in the EN or PN subgroup. Eighteen RCTs including 1790 patients with similar severity of sepsis and ARDS were also analyzed. The OR value was not significantly different in the EN or PN subgroup. Omega-3 fatty acids did not show positive effect on improving mortality of sepsis-induced ARDS (p = 0.39). But in EN subgroup, omega-3 fatty acids treatment seemed to have some benefits in reducing mortality rate (p = 0.04). In the RCTs including similar baseline patients, partial correlation analysis found that the concentration ratio of n-6 to n-3 fatty acids had positive correlation with reduction of mortality (RM) (γ = 0.60, P = 0.02), whereas the total number of each RCT had negative correlation with RM (γ = − 0.54, P = 0.05). Conclusions This review found that omega-3 fatty acid supplementation could reduce the mortality rate of sepsis and sepsis-induced ARDS. However, further investigation based on suitable concentrations and indications is needed to support the findings. |
| first_indexed | 2024-12-22T17:37:53Z |
| format | Article |
| id | doaj.art-a345a68311c2430aa10186eff41926a9 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-22T17:37:53Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-a345a68311c2430aa10186eff41926a92022-12-21T18:18:28ZengBMCNutrition Journal1475-28912018-05-0117111410.1186/s12937-018-0356-8Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trialsHuaiSheng Chen0Su Wang1Ying Zhao2YuTian Luo3HuaSheng Tong4Lei Su5Department of Critical Care Medicine, Guangzhou School of Clinical Medicine, Southern Medical University (Guangzhou General Hospital of Guangzhou Military Region)Department of Cardiovascular and thoracic Surgery, PLA 305 HospitalDepartment of Critical Care Medicine, Institute: Shenzhen People’s Hospital/The Second Clinical Hospital of Jinan UniversityDepartment of Critical Care Medicine, Institute: Shenzhen People’s Hospital/The Second Clinical Hospital of Jinan UniversityDepartment of Critical Care Medicine, Guangzhou School of Clinical Medicine, Southern Medical University (Guangzhou General Hospital of Guangzhou Military Region)Department of Critical Care Medicine, Guangzhou School of Clinical Medicine, Southern Medical University (Guangzhou General Hospital of Guangzhou Military Region)Abstract Objective This study aimed to investigate the possible effect of omega-3 fatty acids on reducing the mortality of sepsis and sepsis-induced acute respiratory distress syndrome (ARDS) in adults. Methods Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) database, WangFang database, and Chinese BioMedical Literature Database from their inception to March 6, 2017, were searched using systematic review researching methods. Five factors were analyzed to investigate the correlation between omega-3 fatty acids (either parenteral or enteral supplementation) and mortality rate. Results Forty randomized controlled trials (RCTs) were initially included, but only 25 of them assessed mortality. Of these RCTs, nine used enteral nutrition (EN) and 16 used parenteral nutrition (PN). The total mortality rate in the omega-3 fatty acid group was lower than that in the control group. However, the odds ratio (OR) value was not significantly different in the EN or PN subgroup. Eighteen RCTs including 1790 patients with similar severity of sepsis and ARDS were also analyzed. The OR value was not significantly different in the EN or PN subgroup. Omega-3 fatty acids did not show positive effect on improving mortality of sepsis-induced ARDS (p = 0.39). But in EN subgroup, omega-3 fatty acids treatment seemed to have some benefits in reducing mortality rate (p = 0.04). In the RCTs including similar baseline patients, partial correlation analysis found that the concentration ratio of n-6 to n-3 fatty acids had positive correlation with reduction of mortality (RM) (γ = 0.60, P = 0.02), whereas the total number of each RCT had negative correlation with RM (γ = − 0.54, P = 0.05). Conclusions This review found that omega-3 fatty acid supplementation could reduce the mortality rate of sepsis and sepsis-induced ARDS. However, further investigation based on suitable concentrations and indications is needed to support the findings.http://link.springer.com/article/10.1186/s12937-018-0356-8SepsisMultiple organs dysfunction syndromeAcute respiratory distress syndromeOmega 3 fatty acidMortality |
| spellingShingle | HuaiSheng Chen Su Wang Ying Zhao YuTian Luo HuaSheng Tong Lei Su Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials Nutrition Journal Sepsis Multiple organs dysfunction syndrome Acute respiratory distress syndrome Omega 3 fatty acid Mortality |
| title | Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials |
| title_full | Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials |
| title_fullStr | Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials |
| title_full_unstemmed | Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials |
| title_short | Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials |
| title_sort | correlation analysis of omega 3 fatty acids and mortality of sepsis and sepsis induced ards in adults data from previous randomized controlled trials |
| topic | Sepsis Multiple organs dysfunction syndrome Acute respiratory distress syndrome Omega 3 fatty acid Mortality |
| url | http://link.springer.com/article/10.1186/s12937-018-0356-8 |
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